原著論文

Inverted Micelle Formation of Cell-penetrating Peptide Studied by Coarse-grained Simulation: Importance of Attractive Force between Cell-penetrating Peptides and Lipid Head Group
Shuhei Kawamoto, Masako Takasu, Takeshi Miyakawa, Ryota Morikawa, Tatsuki Oda, Shiroh Futaki, Hidemi Nagao
J. Chem. Phys. 34(9), 095103 (2011)

Selective Isolation of N-blocked Peptide by combining AspN Digestion, Transamination, and Tosylhydrazine Glass Treatment
Kazuhiro Sonomura, Hiroki Kuyama, Ei-ichi Matsuo, Susumu Tsunasawa, Shiroh Futaki, Osamu Nishimura
Anal. Biochem., 410(2), 214-223 (2011)

Endosomal Escape and the Knockdown Efficiency of Liposomal-siRNA by the Fusogenic Peptide shGALA
Yu Sakurai, Hiroto Hatakeyama, Yusuke Sato, Hidetaka Akita, Kentaro Takayama, Sachiko Kobayashi, Shiroh Futaki, Hideyoshi Harashima
Biomaterials, 32(24), 5733-5742 (2011)

KALA-modified Multi-layered Nanoparticles as Gene Carriers for MHC Class-I Mediated Antigen Presentation for a DNA Vaccine
Sharif M. Shaheen, Hidetaka Akita, Takashi Nakamura, Shota Takayama, Shiroh Futaki, Atsushi Yamashita, Ryo Katoono, Nobuhiko Yui, Hideyoshi Harashima
Biomaterials, 50(28), 6266-6272 (2011)

An Arginine Residue Instead of a Conserved Leucine Residue in the Recognition Helix of the Finger 3 of Zif268 Stabilizes the Domain Structure and Mediates DNA Binding
Shigeru Negi, Miki Imanishi, Maeko Sasaki, Kazuya Tatsutani, Shiroh Futaki, Yukio Sugiura
Biochemistry, 50(28), 6266-6272 (2011)

Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis
Chung Yeng Looi, Miki Imanishi, Satoshi Takaki, Miki Sato, Natsuko Chiba, Yoji Sasahara, Shiroh Futaki, Shigeru Tsuchiya, Satoru Kumaki
PLosOne, 6(8), e23640 (2011)

Control of Circadian Phase by an Artificial Zinc Finger Transcription Regulator
Miki Imanishi, Atsushi Nakamura, Masao Doi, Shiroh Futaki, Hitoshi Okamura
Angew. Chem. Int. Ed. Engl., 50(40), 9396-9399 (2011)

Binding of Tat peptides on DOPC and DOPG lipid bilayer membrane studied by molecular dynamics simulations
Shuhei Kawamoto, Masako Takasu, Takeshi Miyakawa, Ryota Morikawa, Tatsuki Oda, Shiroh Futaki, Hidemi Nagao
Molecular Simulation, DOI:10.1080/08927022.2010.536546

Two-Dimensional Molecular Assembly of Bacteriochlorophyll a Derivatives Using Synthetic Poly(ethylene glycol)-Linked Light-Harvesting Model Polypeptides on a Gold Electrode Modified with Supported Lipid Bilayers
Tsuyoshi Ochiai, Morio Nagata, Kosuke Shimoyama, Tomoya Kato, Takahide Asaoka, Masaharu Kondo, Takehisa Dewa, Keiji Yamashita, Ayumi Kashiwada, Shiroh Futaki, Hideki Hashimoto, Mamoru Nango
ACS Macro Lett., 1(1), 28-32 (2011)

Acylation of Octaarginine: Implication to the Use of Intracellular Delivery Vectors
Sayaka Katayama, Hisaaki Hirose, Kentaro Takayama, Ikuhiko Nakase, Shiroh Futaki
J. Control. Release, 149 (1), 29-35 (2011)

総説類

Mechanisms of Cellular Uptake of Cell Penetrating Peptides
Fatemeh Madani, Staffan Lindberg, Ulo Langel, Shiroh Futaki, Astrid Gräslund
J. Biophys., in press.

膜透過ペプチドの生体膜透過機構と高分子の細胞内導入
二木史朗
膜 (MEMBRANE) , 36(4), 139-144 (2011)

ペプチドベクターを用いた効率的細胞導入法
二木史朗、中瀬生彦
蛍光イメージング/MRIプローブの開発（菊地和也監修）, 173-179 (2011)

原著論文

Enhanced Target-Specific Accumulation of Radiolabeled Antibodies by Conjugating Arginine-Rich Peptides as Anchoring Molecules
Rei Miyamoto, Hiromichi Akizawa, Takeshi Nishikawa, Tomoya Uehara, Yusuke Azuma, Ikuhiko Nakase, Shiroh Futaki, Hirofumi Hanaoka, Yasuhiko Iida, Keigo Endo, Yasushi Arano
Bioconjug. Chem,. 21(11), 2031-2037 (2010)

Zinc Finger-Zinc Finger Interaction between the Transcription Factors, GATA-1 and Sp1
Miki Imanishi, Chika Imamura, Chika Higashi, Wei Yan, Shigeru Negi, Shiroh Futaki, Yukio Sugiura
Biochem. Biophys. Res. Commun., 400(4), 625-630 (2010)

Transduction of Cell-Penetrating Peptides into Induced Pluripotent Stem Cells
Hiroshi Yukawa, Hirofumi Noguchi, Ikuhiko Nakase, Yoshitaka Miyamoto, Koichi Oishi, Nobuyuki Hamajima, Shiroh Futaki, Shuji Hayashi
Cell Transplant, 19(6), 901-909 (2010)

Metal-Stimulated Transcriptional Regulation by an Artificial Zinc Finger Protein
Miki Imanishi, Tomohiro Nakaya, Tatsuya Morisaki, Daisuke Noshiro, Shiroh Futaki, Yukio Sugiura
ChemBioChem, 11(12), 1653-1655 (2010)

Rev-derived Peptides Inhibit HIV-1 Replication by Antagonism of Rev and a Co-receptor, CXCR4
Kazuki Shimane, Eiichi Kodama, Ikuhiko Nakase, Shiroh Futaki, Yasuteru Sakurai, Yasuko Sakagami, Stefan G. Sarafianos, Masao Matsuoka
Int. J. Biochem. Cell Biol., 42(9), 1482-1488 (2010)

Contribution of the Flexible Loop Region to the Function of Staphylococcal Enterotoxin B
Saeko Yanaka, Motonori Kudou, Yoshikazu Tanaka, Takumi Sasaki, Sumiyo Takemoto, Atsuko Sakata, Yukio Hattori, Tomoyuki Koshi, Shiroh Futaki, Kouhei Tsumoto, Toshihiro Nakashima
Protein Eng. Des. Sel., 23(5), 415-421 (2010)

Expressed Protein Ligation for the Preparation of Fusion Proteins with Cell Penetrating Peptides for Endotoxin Removal and Intracellular Delivery
Hao-Hsin Yu, Ikuhiko Nakase, Sílvia Pujals, Hisaaki Hirose, Gen Tanaka, Sayaka Katayama, Miki Imanishi, Shiroh Futaki
Biochim. Biophys. Acta., 798(12), 2249-2257 (2010)

Nanoparticles for ex vivo siRNA Delivery to Dendritic Cells for Cancer Vaccines: Programmed Endosomal Escape and Dissociation
Hidetaka Akita, Kentaro Kogure, Rumiko Moriguchi, Yoshio Nakamura, Tomoko Higashi, Takashi Nakamura, Satoshi Serada, Minoru Fujimoto, Tetsuji Naka, Shiroh Futaki, Hideyoshi Harashima
J. Control. Release, 143(3), 311-317 (2010)

Metal-Assisted Channel Stabilization: Disposition of a Single Histidine on the N-terminus of Alamethicin Yields Channels with Extraordinarily Long Lifetimes
Daisuke Noshiro, Koji Asami, Shiroh Futaki
Biophys. J., 98(9), 1801-1808 (2010)

Cell-Penetrating d-Isomer Peptides of p53 C-Terminus: Long-term Inhibitory Effect on the Growth of Bladder Cancer
Daiji Araki, Kentaro Takayama, Miyabi Inoue, Toyohiko Watanabe, Hiromi Kumon, Shiroh Futaki, Hideki Matsui, Kazuhito Tomizawa
Urology, 75(4), 813-819 (2010)

総説類

Application of a Fusiogenic Peptide GALA for Intracellular Delivery
Ikuhiko Nakase, Kentaro Kogure, Hideyoshi Harashima, Shiroh Futaki
Methods Mol. Biol., 683, 525-533 (2010)

ペプチドをツールとして用いた細胞内への物質輸送
二木史朗 化学フロンティア 生命現象を理解する分子ツール：イメージングから生体機能解析まで（浜地格、二木史朗編）, 111-118 (2010)

Endosome-disruptive Peptides for Improving Cytosolic Delivery of Bioactive Macromolecules
Ikuhiko Nakase, Sachiko Kobayashi, Shiroh Futaki
Biopolymers (Peptide Science), 94 (6), 763-770 (2010)

膜透過性塩基性ペプチドを用いる細胞内送達技術〜その分子機構と応用〜
二木史朗, 中瀬生彦
生物物理, 50(3), 137-140 (2010)

マルチ亜鉛フィンガー型人工転写因子の創製と機能
(Artificial Transcription Factors Based on Multi-Zinc Finger Motifs)
森崎達也, 今西未来, 二木史朗, 杉浦幸雄
薬学雑誌, 130(1), 45-48 (2010)

原著論文

Development of an Intracellularly-Acting Inhibitory Peptide Selective for PKN
Kazuhiro Shiga, Kentaro Takayama, Shiroh Futaki, Jessica E. Hutti, Lewis C. Cantley, Katsuko Ueki, Yoshitaka Ono, Hideyuki Mukai
Biochem. J., 425(2), 445-453 (2009)

Elucidating Cell-Penetrating Peptide Mechanisms of Action for Membrane Interaction, Cellular Uptake, and Translocation Utilizing the Hydrophobic Counter-Anion Pyrenebutyrate
Peter Guterstam, Fatemeh Madani, Hisaaki Hirose, Toshihide Takeuchi, Shiroh Futaki, Samir EL-Andaloussi, Astrid Gräslund, Ülo Langel
Biochim. Biophys. Acta. - Biomembranes, 1788(12), 2509-2517 (2009)

Studies on the Effects of Arginine Residues Introduced to Peptide Ribonucleic Acids (PRNA) on the Complex Stability with RNA
Akihiro Nishino, Nobuya Sawa, Keiko Onodera, Seiji Sakamoto, Yasuyuki Araki, Ikuhiko Nakase, Shiroh Futaki, Yoshihisa Inoue, Takehiko Wada
Nucleic Acids Symp. Ser., (53), 55-56 (2009)

Cell Surface Accumulation of Flock House Virus-derived Peptide Leads to Efficient Internalization via Macropinocytosis
Ikuhiko Nakase, Hisaaki Hirose, Gen Tanaka, Akiko Tadokoro, Sachiko Kobayashi, Toshihide Takeuchi, Shiroh Futaki
Mol. Ther., 17(11), 1868-1876 (2009)

Positive and Negative Cooperativity of Modularly Assembled Zinc Fingers
Miki Imanishi, Atsushi Nakamura, Tatsuya Morisaki, Shiroh Futaki
Biochem. Biophys. Res. Commun., 387(3), 440-443 (2009)

Effect of Polyethyleneglycol Spacer on the Binding Properties of Nuclear Localization Signal-Modified Liposomes to Isolated Nucleus
Dai Kurihara, Hidetaka Akita, Asako Kudo, Tomoya Masuda, Shiroh Futaki, Hideyoshi Harashima
Biol. Pharm. Bull., 32(7), 1303-1306 (2009)

A pH-sensitive Fusogenic Peptide Facilitates Endosomal Escape and Greatly Enhances the Gene Silencing of siRNA-containing Nanoparticles in vitro and in vivo
Hiroto Hatakeyama, Erika Itho, Hidetaka Akita, Motoi Oishi, Yukio Nagasaki, Shiroh Futaki, Hideyoshi Harashima
J. Control. Release, 139(2), 127-132 (2009)

Cobalt(II)-Responsive DNA Binding of a GCN4-bZIP Protein Containing Cysteine Residues Functionalized with Iminodiacetic Acid
Yusuke Azuma, Miki Imanishi, Tomoyuki Yoshimura, Takeo Kawabata, Shiroh Futaki
Angew. Chem. Int. Ed., 48(37), 6853-6856 (2009)

Enhanced Intracellular Delivery Using Arginine-Rich Peptides by the Addition of Penetration Accelerating Sequences (Pas)
Kentaro Takayama, Ikuhiko Nakase, Hiroyuki Michiue, Toshihide Takeuchi, Kazuhito Tomizawa, Hideki Matsui, Shiroh Futaki
J. Control. Release, 138(2), 128-133 (2009)

Efficient Short Interference RNA Delivery to Tumor Cells Using a Combination of Octaarginine, GALA and Tumor-Specific, Cleavable Polyethylene Glycol System
Yu Sakurai, Hiroto Hatakeyama, Hidetaka Akita, Motoi Oishi, Yukio Nagasaki, Shiroh Futaki, Hideyoshi Harashima
Biol. Pharm. Bull., 32(5), 928-932 (2009)

Cellular Uptake, Distribution and Cytotoxicity of the Hydrophobic Cell Penetrating Peptide Sequence PFVYLI Linked to the Proapoptotic Domain Peptide PAD
Catherine L. Watkins, Paul Brennan, Christopher Fegan, Kentaro Takayama, Ikuhiko Nakase, Shiroh Futaki, Arwyn T. Jones
J. Control. Release, 140(3), 237-244 (2009)

Cytosolic Targeting of Macromolecules Using a pH-dependent Fusogenic Peptide in Combination with Cationic Liposomes
Sachiko Kobayashi, Ikuhiko Nakase, Noriko Kawabata, Hao-Hsin Yu, Sílvia Pujals, Miki Imanishi, Ernest Giralt, Shiroh Futaki
Bioconjug. Chem., 20, 953-959 (2009)
PMID: 19388672

High-resolution Multi-dimensional NMR Spectroscopy of Proteins in Human Cells
Kohsuke Inomata, Ayako Ohno, Hidehito Tochio, Shin Isogai, Takeshi Tenno, Ikuhiko Nakase, Toshihide Takeuchi, Shiroh Futaki, Yutaka Ito, Hidekazu Hiroaki, Masahiro Shirakawa
Nature, 458, 106-110 (2009)
PMID: 19262675

Low Concentration Thresholds of Plasma Membranes for Rapid Energy-Independent Translocation of a Cell Penetrating Peptide
Catherine L Watkins, Dirk Schmaljohann, Shiroh Futaki, Arwyn T Jones
Biochem. J., 420, 179-189 (2009)
PMID: 19216719

Novel System to Achieve One-Pot Modification of Cargo Molecules with Oligoarginine Vectors for Intracellular Delivery
Kentaro Takayama, Akiko Tadokoro, Sílvia Pujals, Ikuhiko Nakase, Ernest Giralt, Shiroh Futaki
Bioconjug. Chem., 20, 249-257 (2009)
PMID: 19161253

Transferrin Receptor-dependent Cytotoxicity of Artemisinin-Transferrin Conjugates on Prostate Cancer Cells and Induction of Apoptosis
Ikuhiko Nakase, Byron Gallis, Tomoka Takatani-Nakase, Steve Oh, Eric Lacoste, Narendra P Singh, David R Goodlett, Seigo Tanaka, Shiroh Futaki, Henry Lai, Tomikazu Sasaki
Cancer Lett., 274, 290-298 (2009)
PMID: 19006645

Mesostructured Silica Based Delivery System for a Drug with a Peptide as a Cell-Penetrating Vector
Chuanbo Gao, Isabel Izquierdo-Barba, Ikuhiko Nakase, Shiroh Futaki, Juanfang Ruan, Kazutami Sakamoto, Yasuhiro Sakamoto, Kazuyuki Kuroda, Osamu Terasaki, Shunai Che
Microporous and Mesoporous Materials, 122, 201-207 (2009)

総説類

膜透過ペプチドベクターの開発とメカニズム
中瀬生彦, 二木史朗
生化学, 81(11), 992-995 (2009)

Delivery of Macromolecules using Arginine-Rich Cell Penetrating Peptides: Ways to Overcome Endosomal Entrapment
Ayman El-Sayed, Shiroh Futaki, Hideyoshi Harashima
AAPS J., 11, 13-22 (2009)
PMID: 19125334

「細胞表面を取り巻く化学」
二木史朗
化学レビュー10　生体機能化学　生体機能の謎に迫る！, 64, 48-52 (2009)

原著論文

Oligoarginine-Based Prodrugs with Self-Cleavable Spacers for Caco-2 Cell Permeation
Kentaro Takayama, Yuka Suehisa, Takuya Fujita, Jeffrey-Tri  Nguyen, Shiroh Futaki, Akira Yamamoto, Yoshiaki Kiso, Yoshio Hayashi
Chem. Pharm. Bull., 56(11), 1515-1520 (2008)
PMID: 18981599

Effects of bulkiness and hydrophobicity of an aliphatic amino acid in the recognition helix of the GAGA zinc finger on the stability of the hydrophobic core and DNA binding affinity
Muthu Dhanasekaran, Shigeru Negi, Miki Imanishi, Michiko Suzuki, Yukio Sugiura
Biochemistry, 47(45), 11717-11724 (2008)
PMID: 18855425

Effects of Arginine Residue Introduction upon Interaction and Complexation Behavior of Peptide Ribonucleic Acids (PRNAs) with RNA: Synthesis and Properties of alpha-Containing arginine
Takehiko Wada, Nobuya Sawa, Hirofumi Sato, Shiroh Futaki, Yoshihisa Inoue.
Nucleic Acids Symp. Ser., (52), 673-674 (2008)
PMID: 18776559

Rapid Transcriptional Activity in Vivo and Slow DNA Binding in Vitro by Artificial Multi-Zinc Finger Protein
Tatsuya Morisaki, Miki Imanishi, Shiroh Futaki, Yukio Sugiura
Biochemistry, 47(38), 10171-10177 (2008)
PMID: 18754679

Octaarginine- and Octalysine-Modified Nanoparticles Have Different Modes of Endosomal Escape
Ayman El-Sayed, Ikramy A. Khalil, Kentaro Kogure, Shiroh Futaki, Hideyoshi Harashima
J. Biol. Chem., 283(34), 23450-23461 (2008)
PMID: 18550548

An Artificial Virus-like Nano Carrier System: Enhanced Endosomal escape of Nanoparticles via Synergistic Action of pH-sensitive Fusogenic Peptide Derivatives
Kentaro Sasaki, Kentaro Kogure, Shinji Chaki, Yoshio Nakamura, Rumiko Moriguchi, Hirofumi Hamada, Radostin Danev, Kuniaki Nagayama, Shiroh Futaki, Hideyoshi Harashima
Anal. Bioanal. Chem., 391(8), 2717-2727 (2008)
PMID: 18351325

Cellular Internalization and Distribution of Arginine-Rich Peptides as a Function of Extracellular Peptide Concentration, Serum, and Plasma Membrane Associated Proteoglycans
Michie Kosuge, Toshihide Takeuchi, Ikuhiko Nakase, Arwyn Tomos Jones, Shiroh Futaki
Bioconjug. Chem. 19(3), 656-664 (2008)
PMID: 18269225

総説類

Octaarginine-modified Liposomes: Enhanced Cellular Uptake and Controlled Intracellular Trafficking
Ikramy A. Khalil, Kentaro Kogure, Shiroh Futaki, Hideyoshi Harashima
Int. J. Pharm., 354(1-2), 39-48 (2008)
PMID: 18242018

New Redesigned Zinc-Finger Proteins: Design Strategy and Its Application
Shigeru Negi, Miki Imanishi, Makoto Matsumoto, Yukio Sugiura
Chemistry, 14(11), 3236-3249 (2008)
PMID: 18236477

Membrane Permeable Peptide Vectors: Chemistry and Functional Design for the Therapeutic Applications
Shiroh Futaki
Adv. Drug Deliv. Rev., 60(4-5), 447 (2008)
PMID: 18077052

Methodological and Cellular Aspects that Govern the Internalization Mechanisms of Arginine-rich Cell-penetrating Peptides
Ikuhiko Nakase, Toshihide Takeuchi, Gen Tanaka, Shiroh Futaki
Adv. Drug Deliv. Rev., 60(4-5), 598-607 (2008)
PMID: 18045727

Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation
Ikuhiko Nakase, Henry Lai, Narendra P. Singh, Tomikazu Sasaki
Int. J. Pharm., 354(1-2), 28-33 (2008)
PMID: 17942255

セミナー：膜透過ペプチドを用いる細胞導入技術
二木史朗
ファルマシア, 44(4), 321-325 (2008)

原著論文

Development of Oligoarginine-drug Conjugates Linked to New Peptidic Self-cleavable Spacers toward Effective Intestinal Absorption
Yoshio Hayashi, Kentaro Takayama, Yuka Suehisa, Takuya Fujita, Jeffrey-Tri Nguyen, Shiroh Futaki, Akira Yamamoto, Yoshiaki Kiso
Bioorg. Med. Chem. Lett., 17(18), 5129-5132 (2007)
PMID: 17662604

Guanidine-Containing Molecular Transporters: Sorbitol-Based Transporters Show High Intracellular Selectivity toward Mitochondria
Kaustabh K. Maiti, Woo Sirl Lee, Toshihide Takeuchi, Catherine Watkins, Marjan Fretz, Dong-Chan Kim, Shiroh Futaki, Arwyn Jones, Kyong-Tai Kim, Sung-Kee Chung
Angew. Chem. Int. Ed. Engl., 46(31), 5880-5884 (2007)
PMID: 17607670

Alpha-Helical Linker of an Artificial 6-Zinc Finger Peptide Contributes to Selective DNA Binding to a Discontinuous Recognition Sequence
Wei Yan, Miki Imanishi, Shiroh Futaki, Yukio Sugiura
Biochemistry, 46(29), 8517-8524 (2007)
PMID: 17602503

Octaarginine-modified Multifunctional Envelope-type Nano Device for siRNA
Yoshio Nakamura, Kentaro Kogure, Shiroh Futaki, Hideyoshi Harashima
J. Control. Release, 119(3), 360-367 (2007)
PMID: 17478000

New Packaging Method of Mycobacterial Cell Wall using Octaarginine-modified Liposomes: Enhanced Uptake by and Immunostimulatory Activity of Dendritic Cells
Atthachai Homhuan, Kentaro Kogure, Hideyuki Akaza, Shiroh Futaki, Takashi Naka, Yukiko Fujita, Ikuya Yano, Hideyoshi Harashima
J. Control. Release, 120(1-2), 60-69 (2007)
PMID: 17467840

NMR Investigation of the Electrostatic Effect in Binding of a Neuropeptide, Achatin-I, to Phosphatidylcholine Bilayers
Tomohiro Kimura, Keiko Ninomiya, Shiroh Futaki
J. Phys. Chem. B. 111(14), 3831-3838 (2007)
PMID: 17388516

Octaarginine-modified Multifunctional Envelope-type Nanoparticles for Gene Delivery
I. A. Khalil, K. Kogure, S. Futaki, S. Hama, H. Akita, M. Ueno, H. Kishida, M. Kudoh, Y. Mishina, K. Kataoka, M. Yamada, H. Harashima
Gene Ther., 14(8), 682-689 (2007)
PMID: 17268535

The Use of Acid Wash in Determining Cellular Uptake of Fab/Cell-Permeating Peptide Conjugates
Shouju Kameyama, Mayo Horie, Takeo Kikuchi, Takao Omura, Akiko Tadokoro, Toshihide Takeuchi, Ikuhiko Nakase, Yukio Sugiura, Shiroh Futaki
Biopolymers (Peptide Science), 88(2), 98-106 (2007)
PMID: 17252560

Activation of JNK pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor
H. Noguchi, Y. Nakai, M. Ueda, Y. Masui, S. Futaki, N. Kobayashi, S. Hayashi, S. Matsumoto
Diabetologia, 50(3), 612-619 (2007)
PMID: 17225125

Temperature, Concentration and Cholesterol Dependent Translocation of L- and D-octaarginine across the Plasma and Nuclear membrane of CD34+ Leukaemia Cells
Marjan M. Fretz, Neal A. Penning, Saly Al-Taei, Shiroh Futaki, Toshihide Takeuchi, Ikuhiko Nakase, Gert Storm, Arwyn T. Jones
Biochemical J., 403(2), 335-342 (2007)
PMID: 17217340

Interaction of Arginine-Rich Peptides with Membrane-Associated Proteoglycans Is Crucial for Induction of Actin Organization and Macropinocytosis
Ikuhiko Nakase, Akiko Tadokoro, Noriko Kawabata, Toshihide Takeuchi, Hironori Katoh, Kiyo Hiramoto, Manabu Negishi, Motoyoshi Nomizu, Yukio Sugiura, Shiroh Futaki
Biochemistry, 46(2), 492-501 (2007)
PMID: 17209559

総説類

Arginine-rich peptides and their internalization mechanisms
Shiroh Futaki, Ikuhiko Nakase, Akiko Tadokoro, Toshihide Takeuchi Arwyn Tomos Jones
Biochem. Soc. Trans. 35(Pt 4), 784-787 (2007)
PMID: 17635148

Ligand-Induced Extramembrane Conformation Switch Controlling Alamethicin Assembly and the Channel Current
Shiroh Futaki, Koji Asami
Chem. Biodiv. 4(6), 1313-1322 (2007)
PMID: 17589883

原著論文

Oligomers of Beta-Amino Acid Bearing Non-planar Amides Form Ordered Structures
Yuko Otani, Shiroh Futaki, Tatsuto Kiwada, Yukio Sugiura, Atsuya Muranaka, Nagao Kobayashi, Masanobu Uchiyama, Kentaro Yamaguchi, Tomohiko Ohwada
Tetrahedron, 62(50), 11635-11644 (2006)

Direct and Rapid Cytosolic Delivery Using Cell-Penetrating Peptides Mediated by Pyrenebutyrate
Toshihide Takeuchi, Michie Kosuge, Akiko Tadokoro, Yukio Sugiura, Mayumi Nishi, Mitsuhiro Kawata, Naomi Sakai, Stefan Matile, Shiroh Futaki
ACS Chem. Biol., 1(5), 299-303 (2006)
PMID: 17163758

Autoinhibition Regulates the Motility of the C. Elegans Intraflagellar Transport Motor OSM-3
Miki Imanishi, Nicholas F. Endres, Arne Gennerich, Ronald D. Vale
J. Cell Biol., 174(7), 931-937 (2006)
PMID: 17000874

Effects of Na+/H+ Exchanger Inhibitors on Subcellular Localisation of Endocytic Organelles and Intracellular Dynamics of Protein Transduction Domains HIV-TAT Peptide and Octaarginine
Marjan Fretz, Jing Jin, Robin Conibere, Neal A. Penning, Saly Al-Taei, Gert Storm, Shiroh Futaki, Toshihide Takeuchi, Ikuhiko Nakase, Arwyn T. Jones
J. Control. Release, 116(2), 247-254 (2006)
PMID: 16971016

Cellular Uptake and Subsequent Intracellular Trafficking of R8-liposomes Introduced at Low Temperature
Akitada Iwasa, Hidetaka Akita, Ikramy Khalil, Kentaro Kogure, Shiroh Futaki, Hideyoshi Harashima
Biochim. Biophys. Acta - Biomembranes, 1758(6), 713-720 (2006)
PMID: 16780792

Delivery of Condensed DNA by Liposomal Non-viral Gene Delivery System into Nucleus of Dendritic Cells
Takashi Nakamura, Rumiko Moriguchi, Kentaro Kogure, Arisa Minoura, Tomoya Masuda, Hidetaka Akita, Kazunori Kato, Hirofumi Hamada, Masaharu Ueno, Shiroh Futaki, Hideyoshi Harashima
Biol. Pharm. Bull., 29(6), 1290-1293 (2006)
PMID: 16755037

Effects of Cell-Permeating Peptide Binding on the Distribution of 125I-Labeled Fab Fragment in Rats
Shoju Kameyama, Mayo Horie, Takeo Kikuchi, Takao Omura, Toshihide Takeuchi, Ikuhiko Nakase, Yukio Sugiura, Shiroh Futaki
Bioconjug. Chem., 17(3), 597-602 (2006)
PMID: 16704196

Transmission of Extramembrane Conformational Change into Current; Construction of Metal-gated Ion Channel
Tatsuto Kiwada, Kazuhiro Sonomura, Yukio Sugiura, Koji Asami, Shiroh Futaki
J. Am. Chem. Soc., 128(18), 6010-6011 (2006)
PMID: 16669650

Significant and Prolonged Antisense Effect of a Multifunctional Envelope-type Nano Device Encapsulating Antisense Oligodeoxynucleotide
Yoshio Nakamura, Kentaro Kogure, Yuma Yamada, Shiroh Futaki, Hideyoshi Harashima,
J. Pharm. Pharmacol., 58(4), 431-437 (2006)
PMID: 16597360

Distribution of Immunoglobulin Fab Fragment Conjugated with HIV-1 REV Peptide Following Intravenous Administration in Rats
Shouju Kameyama, Ritsuko Okada, Takeo Kikuchi, Takao Omura, Ikuhiko Nakase, Toshihide Takeuchi, Yukio Sugiura, Shiroh Futaki
Mol. Pharm. 3(2), 174-180 (2006)
PMID: 16579646

Design, Synthesis, and Membrane-Translocation Studies of Inositol-Based Transporters
Kaustabh K. Maiti, Ock-Youm Jeon, Woo Sirl Lee, Dong-Chan Kim, Kyong-Tai Kim, Toshihide Takeuchi, Shiroh Futaki, Sung-Kee Chung
Angew. Chem. Int. Ed. Engl., 45(18), 2907-2912 (2006)
PMID: 16555349

Intracellular Traffic and Fate of Protein Transduction Domains HIV-1 TAT Peptide and Octaarginine. Implications for their Utilization as Drug Delivery Vectors
Saly Al Taei, Neal A. Penning, Jeremy C. Simpson, Shiroh Futaki, Toshihide Takeuchi, Ikuhiko Nakase, Arwyn T. Jones
Bioconjug. Chem., 17(1), 90-100 (2006)
PMID: 16417256

High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression
Ikramy A. Khalil, Kentaro Kogure, Shiroh Futaki, Hideyoshi Harashima
J. Biol. Chem., 281(6), 3544-3551 (2006)
PMID: 16326716

Evaluation of the Nuclear Delivery and Intra-nuclear Transcription of Plasmid DNA Condensed with micro (mu) and NLS-micro by Cytoplasmic and Nuclear Microinjection: A Comparative Study with Poly-L-lysine
Hidetaka Akita, Mitsuhide Tanimoto, Tomoya Masuda, Kentaro Kogure, Susumu Hama, Keiko Ninomiya, Shiroh Futaki, Hideyoshi Harashima
J. Gene Med., 8(2), 198-206 (2006)
PMID: 16285003

総説類

分子集合体の細胞内デリバリー
二木史朗
臨床検査, 50(12), 1439-1546 (2006) （臨床検査増刊号,ナノテクノロジーとバイオセンサ）

Oligoarginine Vectors for Intracellular Delivery: Design and Cellular-uptake Mechanisms
Shiroh Futaki
Biopolymers (Peptide Science), 84(3), 241-249 (2006)
PMID: 16333858

Anion Hopping of (and on) Functional Oligoarginines: From Chloroform to Cells
Naomi Sakai, Shiroh Futaki, Stefan Matile
Soft Matter, 2(8), 636-641 (2006)

トピックス：ペプチドベクターを用いた細胞内移送
二木史朗
酵素工学ニュース第55号, 平成18年4月号, 8-11

ペプチドによる細胞内移送制御
二木史朗
高分子, 55(5), 345 (2006)

遺伝子を標的とした人工亜鉛フィンガータンパク質の創製
今西未来
化学工業, 57(9), 667-671 (2006)

原著論文

PDX-1 Protein Is Internalized by Lipid Raft-dependent Macropinocytosis
Hirofumi Noguchi, Shinichi Matsumoto, Teru Okitsu, Yasuhiro Iwanaga, Yukihide Yonekawa, Hideo Nagata, Masayuki Matsushita, Fan-Yan Wei, Hideki Matsui, Kohtaro Minami, Susumu Seino, Yumi Masui, Shiroh Futaki, Koichi Tanaka
Cell Transplantation, 14(9), 637-645 (2005)
PMID: 16405074

Real-time In-cell ¹⁹F NMR Study on Uptake of Fluorescent and Nonfluorescent ¹⁹F-Octaarginines into Human Jurkat Cells
Emiko Okamura, Keiko Ninomiya, Shiroh Futaki, Yasuharu Nagai, Tomohiro Kimura, Chihiro Wakai, Nobuyuki Matubayasi, Yukio Sugiura, Masaru Nakahara
Chem. Lett., 34(7), 1064-1065 (2005)

Pharmacokinetic Analysis of the Tissue Distribution of Octaarginine Modified Liposomes in Mice
Diky Mudhakir, Hidetaka Akita, Ikramy A. Khalil, Shiroh Futaki, Hideyoshi Harashima
Drug Metab. Pharmacokinet., 20(4), 275-281 (2005)
PMID: 16141607

Mitochondrial Delivery of Mastoparan with Transferrin Liposomes Equipped with a pH-sensitive Fusogenic Peptide for Selective Cancer Therapy
Yuma Yamada, Yasuo Shinohara, Tomoyuki Kakudo, Shinji Chaki, Shiroh Futaki, Hiroyuki Kamiya, Hideyoshi Harashima
Int. J. Pharm., 303(1-2), 1-7 (2005)
PMID: 16139452

Unique Features of a pH-sensitive Fusogenic Peptide that Improves the Transfection Efficiency of Cationic Liposomes
Shiroh Futaki, Yumi Masui, Ikuhiko Nakase, Yukio Sugiura, Takashi Nakamura, Kentaro Kogure, and Hideyoshi Harashima
J. Gene Med., 7(11), 1450-1458 (2005)
PMID: 16025556

A Multifunctional Envelope-type Nano Device for Novel Gene Delivery of siRNA Plasmids.
Rumiko Moriguchi, Kentaro Kogure, Hidetaka Akita, Shiroh Futaki, Makoto Miyagishi, Kazunari Taira, Hideyoshi Harashima
Int. J. Pharm., 301(1-2), 277-85 (2005)
PMID: 16019173

Cell Permeable Peptide of JNK Inhibitor Prevents Islet Apoptosis Immediately after Isolation and Improves Islet Graft Function
Hirofumi Noguchi, Yusuke Nakai, Shinichi Matsumoto, Miho Kawaguchi, Michiko Ueda, Teru Okitsu, Yasuhiro Iwanaga, Yukihide Yonekawa, Hideo Nagata, Kohtaro Minami, Susumu Seino, Yumi Masui, Shiroh Futaki, Koichi Tanaka
Am. J. Transplant., 5(8), 1848-1855 (2005)
PMID: 15996231

An Artificial Six-Zinc Finger Peptide With Polyarginine Linker: Selective Binding to the Discontinuous DNA Sequences
Miki Imanishi, Yan Wei, Tatsuya Morisaki, Yukio Sugiura
Biochem Biophys Res Commun., 333(1), 167-73 (2005)
PMID: 15939400

Arginine Magic With New Counterions Up the Sleeve
Masamichi Nishihara, Florent Perret, Toshihide Takeuchi, Shiroh Futaki, Adina N. Lazar, Anthony W. Coleman, Naomi Sakai, Stefan Matile
Org. Biomol. Chem., 3(9), 1659-1669 (2005)
PMID: 15858647

Effects of Linking 15-Zinc Finger Domains on DNA Binding Specificity and Multiple DNA Binding Modes
Tsuyoshi Hirata, Wataru Nomura, Miki Imanishi, Yukio Sugiura
Bioorg Med Chem Lett., 15(9), 2197-2201 (2005)
PMID: 15837293

Site-Specific DNA Cleavage by Artificial Zinc Finger-Type Nuclease with Cerium-Binding Peptide
Takako Nakatsukasa, Yasuhisa Shiraishi, Shigeru Negi, Miki Imanishi, Shiroh Futaki, Yukio Sugiura
Biochem. Biophys. Res. Commun., 330(1), 247-252 (2005)
PMID: 15781257

Swapping of the Beta-Hairpin Region between Sp1 and GLI Zinc Fingers: Significant Role of the Beta-Hairpin Region in DNA Binding Properties of C2H2-Type Zinc Finger Peptides
Yasuhisa Shiraishi, Miki Imanishi, Tatsuya Morisaki, Yukio Sugiura
Biochemistry, 44(7), 2523-2528 (2005)
PMID: 15709764

Anionic Fullerenes, Calixarenes, Coronenes, and Pyrenesas Activators of Oligo/Polyarginines in Model Membranes and Live Cells
Florent Perret, Masamichi Nishihara, Toshihide Takeuchi, Shiroh Futaki, Adina N. Lazar, Anthony W. Coleman, Naomi Sakai, Stefan Matile
J. Am. Chem. Soc., 127(4), 1114-1115 (2005)
PMID: 15669846

総説類

膜透過ペプチドを用いた蛋白質細胞内移送
二木史朗
化学と生物, 43(10), 649-653 (2005)

塩基性ペプチドとのハイブリッド化によるタンパク質・薬物の効率的細胞内導入
二木史朗
Bio Industry, 22(3), 34-39 (2005)

Membrane-permeable Arginine-rich Peptides and the Translocation Mechanisms
Shiroh Futaki
Adv. Drug Deliv. Rev., 57(4), 547-558 (2005)
PMID: 15722163

原著論文

NMR Structure of Transcription Factor Sp1 DNA Binding Domain
Shinichiro Oka, Yasuhisa Shiraishi, Takuya Yoshida, Tadayasu Ohkubo, Yukio Sugiura, Yuji Kobayashi
Biochemistry, 43(51), 16027-16035 (2004)
PMID: 15609997

Control of Peptide Structure and Recognition by Fe(III)-induced Helix Destabilization
Shiroh Futaki, Tatsuto Kiwada, Yukio Sugiura
J. Am. Chem. Soc., 126(48), 15762-15769 (2004)
PMID: 15571399

Cellular Uptake of Arginine-Rich Peptides: Roles for Macropinocytosis and Actin Rearrangement
Ikuhiko Nakase, Miki Niwa, Toshihide Takeuchi, Kazuhiro Sonomura, Noriko Kawabata, Yukihiro Koike, Masanori Takehashi, Seigo Tanaka, Kunihiro Ueda, Jeremy C. Simpson, Arwyn T. Jones, Yukio Sugiura, Shiroh Futaki
Mol. Ther., 10(6), 1011-1022 (2004)
PMID: 15564133

Direct Observation of Anion-Mediated Translocation of Fluorescent Oligoarginine Carriers Into and Across Bulk Liquid and Anionic Bilayer Membranes
Naomi Sakai, Toshihide Takeuchi, Shiroh Futaki, Stefan Matile
ChemBioChem, 6(1), 114-122 (2005)
(Published on-line: November 17, 2004)
PMID: 15549725

Creation and Characteristics of Unnatural CysHis(3)-Type Zinc Finger Protein
Shigeru Negi, Masako Itazu, Miki Imanishi, Akiko Nomura, Yukio Sugiura
Biochem Biophys Res Commun., 325(2), 421-425 (2004)
PMID: 15530409

RNase S Complex Bearing Arginine-rich Peptide and Anti-HIV Activity
Shiroh Futaki, Ikuhiko Nakase, Tomoki Suzuki, Daisuke Nameki, Ei-ichi Kodama, Masao Matsuoka, Yukio Sugiura
J. Mol. Recogn., 18(2), 169-174 (2004)
PMID: 15476294

Development of a Non-viral Multifunctional Envelop-Type Nano Device by a Novel Lipid Film Hydration Method
Kentaro Kogure, Rumiko Moriguchi, Kentaro Sasaki, Masaharu Ueno, Shiroh Futaki, Hideyoshi Harashima
J. Control. Release, 98(2), 317-323 (2004)
PMID: 15262422

Exchange of Histidine Spacing Between Sp1 and GLI Zinc Fingers: Distinct Effect of Histidine Spacing-Linker Region on DNA Binding
Yasuhisa Shiraishi, Miki Imanishi, Yukio Sugiura
Biochemistry, 43(20), 6352-6359 (2004)
PMID: 15147220

Arginine Carrier Peptide Bearing Ni(II) Chelator to Promote Cellular Uptake of Histidine-Tagged Proteins
Shiroh Futaki, Miki Niwa, Ikuhiko Nakase, Akiko Tadokoro, Youjun Zhang, Makoto Nagaoka, Noaya Wakako, Yukio Sugiura
Bioconjug. Chem., 15(3), 475-481 (2004)
PMID: 15149174

Transferrin-modified Liposomes Equipped with a pH-sensitive Fusogenic Peptide: an Artificial Viral-like Delivery System
Tomoyuki Kakudo, Shinji Chaki, Shiroh Futaki, Ikuhiko Nakase, Kenichi Akaji, Toru Kawakami, Kazuo Maruyama, Hiroyuki Kamiya, Hideyoshi Harashima
Biochemistry, 43(19), 5618-5628 (2004)
PMID: 15134436

Total Synthesis of Artificial Zinc Finger Proteins: Problems and Perspectives
Shiroh Futaki, Tatsuto Kiwada, Yasuhisa Shiraishi, Yukio Sugiura
Biopolymers (Peptide Science), 76(2), 98-109 (2004)
PMID: 15054890

Gramicidin-based Channel Systems for the Detection of Protein-ligand Interaction
Shiroh Futaki, Youjun Zhang, Tatsuto Kiwada, Ikuhiko Nakase, Takeshi Yagami, Shigetoshi Oiki, Yukio Sugiura
Bioorg. Med. Chem., 12(6), 1343-1350 (2004)
PMID: 15018906

Quantitative Three-dimensional Analysis of the Intracellular Trafficking of Plasmid DNA Transfected by Non-viral Gene Delivery System using Confocal Laser Scanning Microscopy
Hidetaka Akita, Rie Ito, Ikramy A. Khalil, Shiroh Futaki, Hideyoshi Harashima
Mol. Ther., 9(3), 443-451 (2004)
PMID: 15006612

Total Synthesis of Large CCK Isomers Using a Thioester Segment Condensation Approach
Kouki Kitagawa, Hiroshi Adachi, Yuki Sekigawa, Takeshi Yagami, Shiroh Futaki, Yuan Jun Gu, Kazutomo Inoue
Tetrahedron, 60(4), 907-918 (2004)

Mechanism of Improved Gene Transfer by the N-Terminal Stearylation of Octaarginine: Enhanced Cellular association by Hydrophobic Core Formation
Ikramy A. Khalil, Shiroh Futaki, Miki Niwa, Yoshinobu Baba, Noridata Kaji, Hiroyuki Kamiya, Hideyoshi Harashima
Gene Ther., 11(7), 636-644 (2004)
PMID: 14973542

Alpha, Alpha-Disubstituted Glycines Bearing a Large Hydrocarbon Ring. Peptide Self-Assembly through Novel Hydrophobic Recognition
Tomohiko Ohwada, Daisuke Kojima, Tatsuto Kiwada, Shiroh Futaki, Yukio Sugiura, Kentaro Yamaguchi, Yoshinori Nishi, Yuji Kobayashi
Chemistry- A Eur J., 10(3) 617-626 (2004)
PMID: 14767925

総説類

ペプチドによるドラッグデリバリー
二木史朗
細胞, 36(10), 428-431 (2004)

アルギニンペプチドによる細胞内デリバリー
二木史朗
薬剤学, 64(3), 164-167 (2004)

原著論文

pH-sensitive Liposomes in Nuclear Targeting of Macromolecules
Rieko Tachibana, Shiroh Futaki, Hideysoshi Harashima, Hiroshi Kiwada
Methods Enzymol., 372, 349-361(2003)
PMID: 14610823

Synthetic Copoly(Lys/Phe) and Poly(Lys) Translocate through Lipid Bilayer Membranes
Akira Shibata, Syuichi Murata, Satoru Ueno, Shaoqian Liu, Shiroh Futaki, Yoshinobu Baba
Biochim. Biophys, Acta - Biomembranes, 1616(2), 147-155 (2003)
PMID: 14561472

DNA Cleavage Characteristics of Non-protein Enediyne Antibiotic N1999A2
Naoko Miyagawa, Daisuke Sasaki, Mieko Matsuoka, Miki Imanishi, Toshihiko Ando, Yukio Sugiura
Biochem Biophys Res Commun., 306(1), 87-92 (2003)
PMID: 12788070

Can Nuclear Localization Signals Enhance Nuclear Localization of Plasmid DNA?
Takeshi Nagasaki, Teruhiko Myohoji, Taro Tachibana, Shiroh Futaki, Seizo Tamagaki
Bioconjug. Chem., 14(2), 282-286 (2003)
PMID: 12643737

Influence of TFIIIA-type Linker at the N- or C-terminal of Nine-zinc Finger Protein on DNA-Binding Site
Wataru Nomura, Makoto Nagaoka, Yasuhisa Shiraishi, Yukio Sugiura
Biochem Biophys Res Commun., 300(1), 87-92 (2003)
PMID: 12480525

総説類

Membrane-permeability Commonly Shared among Arginine-rich Peptides
Shiroh Futaki, Susumu Goto, Yukio Sugiura
J. Mol. Recog. 16(5), 260 - 264 (2003)
PMID: 14523938

細胞内への物質導入
二木史朗
遺伝子医学別冊「ドラッグデリバリーシステムDDS技術の新たな展開とその活用法」（田畑泰彦編集）, 18-22 (2003)

ペプチドによるドラッグデリバリー
二木史朗
現代医療, 75(7) 233-238 (2003)

Structural Variety of Membrane Permeable Peptides
Shiroh Futaki, Susumu Goto, Tmoki Suzuki, Ikuhiko Nakase, Yukio Sugiura
Curr. Prot. Pept. Sci., 4(2) 87-96 (2003)
PMID: 12678848

膜透過ペプチドを用いた生体高分子の細胞内輸送
二木史朗
膜, 28(2) 55-60 (2003)

原著論文

Generation of Reactive Oxygen Species and Activation of NF-kappaB by non-Abeta Component of Alzheimer's Disease Amyloid
Seigo Tanaka, Masanori Takehashi, Naomi Matoh, Shinya Iida, Tomoki Suzuki, Shiroh Futaki, Hirofumi Hamada, Eliezer Masliah, Yukio Sugiura, Kunihiro Ueda
J. Neurochem., 82(2), 305-315 (2002)
PMID: 12124431

Interconversion between Serine and Aspartic Acid in the Alpha Helix of the N-terminal Zinc Finger of Sp1: Implication for General Recognition Code and for Design of Novel Zinc Finger Peptide Recognizing Complementary Strand
Makoto Nagaoka, Yasuhisa Shiraishi, Yumiko Uno, Wataru Nomura, Yukio Sugiura
Biochemistry, 41(28), 8819-8825 (2002)
PMID: 12102624

Translocation of Branched-chain Arginine Peptides through Cell Membranes: Flexibility in the Spatial Disposition of Positive Charges in Membrane-permeable Peptides
Shiroh Futaki, Ikuhiko Nakase, Tomoki Suzuki, Youjun Zhang, Yukio Sugiura
Biochemistry, 41(25), 7925-7930 (2002)
PMID: 12069581

Detection of Protein-ligand Interaction on the Membranes Using C-terminus Biotin-tagged Alamethicin
Zhang Youjun, Shiroh Futaki, Tatsuto Kiwada, Yukio Sugiura
Bioorg. Med. Chem., 10(8), 2635-2639 (2002)
PMID: 12057652

Topological Stability and Self-Association of a Completely Hydrophobic Model Transmembrane Helix in Lipid Bilayers
Yoshiaki Yano, Tomokazu Takemoto, Satoe Kobayashi, Hiroyuki Yasui, Hiromu Sakurai, Wakana Ohashi, Miki Niwa, Shiroh Futaki, Yukio Sugiura, Katsumi Matsuzaki
Biochemistry, 41(9), 3073-3080 (2002)
PMID: 11863446

Artificial DNA-Bending Six-Zinc Finger Peptides with Different Charged Linkers: Distinct Kinetic Properties of DNA Bindings
Miki Imanishi, Yukio Sugiura
Biochemistry, 41(4), 1328-1334 (2002)
PMID: 11802734

Kinetic Analysis of the Interaction between Vitronectin and the Urokinase Receptor
Yuushi Okumura, Yuichi Kamikubo, Scott A. Curriden, Jieyi Wang, Tatsuto Kiwada, Shiroh Futaki, Kouki Kitagawa, David J. Loskutoff
J. Biol. Chem., 277(11), 9395-9404 (2002)
PMID: 11773078

Possible Existence of Common Internalization Mechanisms among Arginine-rich Peptides
Tomoki Suzuki, Shiroh Futaki, Miki Niwa, Seigo Tanaka, Kunihiro Ueda, Yukio Sugiura
J. Biol. Chem., 277(4), 2437-2443 (2002)
PMID: 11711547

総説類

細胞膜を透過する塩基性ペプチド−蛋白質・薬物の細胞内導入への可能性
二木史朗
蛋白質核酸酵素, 47(11), 1415-1419 (2002)

Arginine-rich Peptides: Potential for Intracellular Delivery of Macromolecules and the Mystery of the Translocation mechanisms
Shiroh Futaki
Int. J. Pharmaceutics, 245(1-2), 1-7 (2002)
PMID: 12270237