ケミカルバイオロジー 京都大学 上杉研究室
開始行:
*代表的論文 [#n710f466]
Jung, D., Abu-Elheiga, L., Ayuzawa, R., Gu, Z., Shirakawa...
''Mis-localization and inhibition of ACC1 by a synthetic ...
Biochem J. 448(3), 409-416 (2012).
Minami, I., Yamada, K., Otsuji, T.G., Yamamoto, T., Shen,...
''A small molecule that promotes cardiac differentiation ...
Cell Reports 2(5), 1448-1460 (2012).
Kamisuki, S., Shirakawa T., Kugimiya, A., Abu-Elheiga, L....
''Synthesis and evaluation of diarylthiazole derivatives ...
J. Med. Chem. 54(13), 4923-4927 (2011).~
~
Kawazoe, Y., Shimogawa, H., Sato, A., Uesugi, M.~
''A mitochondrial surface-specific fluorescent probe acti...
Angew. Chem. Int. Ed. 50(24), 5478-5481 (2011).
Murata, A., Sato, S., Kawazoe, Y., Uesugi, M. ~
''Small-molecule fluorescent probes for specific RNA targ...
Chem. Comm. 47(16), 4712 - 4714 (2011).
Sumiya, E., Shimogawa, H., Sasaki, H., Tsutsumi, M., Yosh...
''Cell-morphology profiling of a natural product library ...
ACS Chem. Biol. 6, 425-431 (2011).~
~
Shirakawa, T. Kawazoe, Y., Tsujikawa, T., Jung, D., Sato,...
''Deactivation of STAT6 through Serine 707 phosphorylatio...
J. Biol. Chem. 286, 4003-4010 (2011).~
[[[Summary>http://www.ncbi.nlm.nih.gov/pubmed/21123173]]]~
~
Sato, S., Murata, A., Orihara, T., Shirakawa, T., Suenaga...
''Marine natural product aurilide activates the OPA1-medi...
Chem. Biol. 18 (1), 31-139 (2011).~
[[[Summary>http://www.ncbi.nlm.nih.gov/pubmed/21276946]]]~
Sato, S. Murata, A., Shirakawa, T., Uesugi, M.~
''Biochemical target isolation for novices: Affinity-base...
Chem. Biol. 17 (6), 616-623 (2010).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/20609411]]~
~
Kamisuki, S., Mao, Q., Abu-Eliheiga, L., Gu, Z., Kugimiya...
''A small molecule that blocks fat synthesis by inhibitin...
Chem. Biol. 16 (8), 882-892 (2009).~
~
~
Yamazoe, S., Shimogawa, H., Sato, S., Esko, J. D., Uesugi...
''A dumbbell-shaped small molecule that promotes cell adh...
Chem. Biol. 16 (7), 773-782 (2009)~
&ref(C&B2009_Yamazoe.pdf,noicon,noimg,nolink,[Fulltext] );~
~
Jung, D., Shimogawa, H., Kwon, Y., Mao, Q., Sato, S., Kam...
''Wrenchnolol derivative optimized for gene activation in...
J. Am. Chem. Soc. 131(13), 4774-4782 (2009)~
&ref(JACS_2009_Jung.pdf,noicon,noimg,nolink,[Fulltext] );~
~
Sato, S., Kwon, Y., Kamisuki, S., Srivastava, N., Mao, Q....
''Polyproline-rod approach to isolating protein targets o...
J. Am. Chem. Soc. 129(4), 873-880 (2007)~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/17243824?d...
~
Choi, Y., Shimogawa, H., Murakami, K., Ramdas, L., Zhang,...
''Chemical genetic identification of the IGF-linked pathw...
Chem. Biol, 13, 241-249 (2006).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/16638529?d...
~
Kawazoe, Y., Tanaka, H., Uesugi, M.~
''Chemical genetic identification of histamine receptor H...
Chem. Biol.11, 907-913 (2004).~
~
Kwon,Y., Arndt, H., Mao, Q., Choi, Y., Kawazoe, Y., Derva...
''Small molecule transcription factor mimic.''~
J. Am. Chem. Soc. 126, 15940-15941 (2004).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/15584709?d...
~
Shimogawa, H., Kwon, Y., Mao, Q., Kawazoe, Y., Choi, Y., ...
''A wrench-shaped synthetic molecule that modulates a tra...
J. Am. Chem. Soc. 126, 3461-3471 (2004).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/15025473?d...
~
Asada, S., Choi, Y., & Uesugi, M.~
''A gene-expression inhibitor that targets an alpha-helix...
J. Am. Chem. Soc. 125, 4992-4993 (2003).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12708845?d...
~
Choi, Y., Kawazoe, Y., Murakami, K., Misawa, H., & Ue...
''Identification of bioactive molecules by adipogenesis p...
J. Biol. Chem. 278, 7320-7324 (2003).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12496288?d...
~
Asada, S., Choi, Y., Yamada, M., Wang, S., Hung, M., Qin,...
''External control of Her2 expression and cancer cell gro...
Proc. Natl. Acad. Sci. USA 99, 12747-12752 (2002).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12242338?d...
~
Choi, Y., Asada, S., & Uesugi, M.~
''Divergent hTAF(II)31-binding motifs hidden in activatio...
J. Biol. Chem. 275, 15912-15916 (2000) .~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/10821850?d...
~
Uesugi, M. & Verdine, G. L.~
''The alpha helical FXXphiphi motif in p53: TAF interacti...
Proc. Natl. Acad. Sci. USA 96, 14801-14806 (1999) .~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/10611293?d...
~
Nyanguile, O., Uesugi, M., Austin, D. J., & Verdine, ...
''A non-natural transcriptional coactivator.''~
Proc. Natl. Acad. Sci. USA 94, 13402-13406 (1997) .~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/9391036?do...
~
Uesugi, M., Nyanguile, O., Lu, H., Levine, A. J., & V...
''Induced alpha helix in the VP16 activation domain upon ...
Science 277, 1310-1313 (1997) .~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/9271577?do...
終了行:
*代表的論文 [#n710f466]
Jung, D., Abu-Elheiga, L., Ayuzawa, R., Gu, Z., Shirakawa...
''Mis-localization and inhibition of ACC1 by a synthetic ...
Biochem J. 448(3), 409-416 (2012).
Minami, I., Yamada, K., Otsuji, T.G., Yamamoto, T., Shen,...
''A small molecule that promotes cardiac differentiation ...
Cell Reports 2(5), 1448-1460 (2012).
Kamisuki, S., Shirakawa T., Kugimiya, A., Abu-Elheiga, L....
''Synthesis and evaluation of diarylthiazole derivatives ...
J. Med. Chem. 54(13), 4923-4927 (2011).~
~
Kawazoe, Y., Shimogawa, H., Sato, A., Uesugi, M.~
''A mitochondrial surface-specific fluorescent probe acti...
Angew. Chem. Int. Ed. 50(24), 5478-5481 (2011).
Murata, A., Sato, S., Kawazoe, Y., Uesugi, M. ~
''Small-molecule fluorescent probes for specific RNA targ...
Chem. Comm. 47(16), 4712 - 4714 (2011).
Sumiya, E., Shimogawa, H., Sasaki, H., Tsutsumi, M., Yosh...
''Cell-morphology profiling of a natural product library ...
ACS Chem. Biol. 6, 425-431 (2011).~
~
Shirakawa, T. Kawazoe, Y., Tsujikawa, T., Jung, D., Sato,...
''Deactivation of STAT6 through Serine 707 phosphorylatio...
J. Biol. Chem. 286, 4003-4010 (2011).~
[[[Summary>http://www.ncbi.nlm.nih.gov/pubmed/21123173]]]~
~
Sato, S., Murata, A., Orihara, T., Shirakawa, T., Suenaga...
''Marine natural product aurilide activates the OPA1-medi...
Chem. Biol. 18 (1), 31-139 (2011).~
[[[Summary>http://www.ncbi.nlm.nih.gov/pubmed/21276946]]]~
Sato, S. Murata, A., Shirakawa, T., Uesugi, M.~
''Biochemical target isolation for novices: Affinity-base...
Chem. Biol. 17 (6), 616-623 (2010).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/20609411]]~
~
Kamisuki, S., Mao, Q., Abu-Eliheiga, L., Gu, Z., Kugimiya...
''A small molecule that blocks fat synthesis by inhibitin...
Chem. Biol. 16 (8), 882-892 (2009).~
~
~
Yamazoe, S., Shimogawa, H., Sato, S., Esko, J. D., Uesugi...
''A dumbbell-shaped small molecule that promotes cell adh...
Chem. Biol. 16 (7), 773-782 (2009)~
&ref(C&B2009_Yamazoe.pdf,noicon,noimg,nolink,[Fulltext] );~
~
Jung, D., Shimogawa, H., Kwon, Y., Mao, Q., Sato, S., Kam...
''Wrenchnolol derivative optimized for gene activation in...
J. Am. Chem. Soc. 131(13), 4774-4782 (2009)~
&ref(JACS_2009_Jung.pdf,noicon,noimg,nolink,[Fulltext] );~
~
Sato, S., Kwon, Y., Kamisuki, S., Srivastava, N., Mao, Q....
''Polyproline-rod approach to isolating protein targets o...
J. Am. Chem. Soc. 129(4), 873-880 (2007)~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/17243824?d...
~
Choi, Y., Shimogawa, H., Murakami, K., Ramdas, L., Zhang,...
''Chemical genetic identification of the IGF-linked pathw...
Chem. Biol, 13, 241-249 (2006).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/16638529?d...
~
Kawazoe, Y., Tanaka, H., Uesugi, M.~
''Chemical genetic identification of histamine receptor H...
Chem. Biol.11, 907-913 (2004).~
~
Kwon,Y., Arndt, H., Mao, Q., Choi, Y., Kawazoe, Y., Derva...
''Small molecule transcription factor mimic.''~
J. Am. Chem. Soc. 126, 15940-15941 (2004).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/15584709?d...
~
Shimogawa, H., Kwon, Y., Mao, Q., Kawazoe, Y., Choi, Y., ...
''A wrench-shaped synthetic molecule that modulates a tra...
J. Am. Chem. Soc. 126, 3461-3471 (2004).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/15025473?d...
~
Asada, S., Choi, Y., & Uesugi, M.~
''A gene-expression inhibitor that targets an alpha-helix...
J. Am. Chem. Soc. 125, 4992-4993 (2003).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12708845?d...
~
Choi, Y., Kawazoe, Y., Murakami, K., Misawa, H., & Ue...
''Identification of bioactive molecules by adipogenesis p...
J. Biol. Chem. 278, 7320-7324 (2003).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12496288?d...
~
Asada, S., Choi, Y., Yamada, M., Wang, S., Hung, M., Qin,...
''External control of Her2 expression and cancer cell gro...
Proc. Natl. Acad. Sci. USA 99, 12747-12752 (2002).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12242338?d...
~
Choi, Y., Asada, S., & Uesugi, M.~
''Divergent hTAF(II)31-binding motifs hidden in activatio...
J. Biol. Chem. 275, 15912-15916 (2000) .~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/10821850?d...
~
Uesugi, M. & Verdine, G. L.~
''The alpha helical FXXphiphi motif in p53: TAF interacti...
Proc. Natl. Acad. Sci. USA 96, 14801-14806 (1999) .~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/10611293?d...
~
Nyanguile, O., Uesugi, M., Austin, D. J., & Verdine, ...
''A non-natural transcriptional coactivator.''~
Proc. Natl. Acad. Sci. USA 94, 13402-13406 (1997) .~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/9391036?do...
~
Uesugi, M., Nyanguile, O., Lu, H., Levine, A. J., & V...
''Induced alpha helix in the VP16 activation domain upon ...
Science 277, 1310-1313 (1997) .~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/9271577?do...
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