Uesugi Laboratory
代表的論文 †
Kamisuki, S., Mao, Q., Abu-Eliheiga, L., Gu, Z., Kugimiya, A., Kwon, Y., Shinohara, T., Kawazoe, Y., Sato, S. Asakura, K., Choo, H., Sakai, J., Wakil, SJ., Uesugi, M.
A Small Molecule that Blocks Fat Synthesis by Inhibiting the Activation of SREBP.
Chem. Bilo. 16 (8), 882-892(2009).
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Yamazoe, S., Shimogawa, H., Sato, S., Esko, J. D., Uesugi, M.
A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth.
Chem. Biol. 16 (7), 773-782 (2009)
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Jung, D., Shimogawa, H., Kwon, Y., Mao, Q., Sato, S., Kamisuki, S., Kigoshi, H., Uesugi, M.
Wrenchnolol Derivative Optimized for Gene Activation in Cells.
J. Am. Chem. Soc. 131(13), 4774-4782 (2009)
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Sato, S., Kwon, Y., Kamisuki, S., Srivastava, N., Mao, Q., Kawazoe, Y., Uesugi, M.
Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin.
J. Am. Chem. Soc. 129(4), 873-880 (2007)
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Choi, Y., Shimogawa, H., Murakami, K., Ramdas, L., Zhang, W., Qin, J., Uesugi,M.
Chemical Genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2
Chemistry＆Biology, 13, 241-249 (2006)．
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Kwon,Y., Arndt, H., Mao, Q., Choi, Y., Kawazoe, Y., Dervan, P. B., Uesugi, M.
Small molecule transcription factor mimic.
J. Am. Chem. Soc. 126, 15940-15941 (2004).
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Shimogawa, H., Kwon, Y., Mao, Q., Kawazoe, Y., Choi, Y., Asada, S., Kigoshi, H., & Uesugi, M.
A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.
J. Am. Chem. Soc. 126, 3461-3471 (2004).
[Summary] [Full text] [C&EN(PDF)]
Asada, S., Choi, Y., & Uesugi, M.
A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction.
J. Am. Chem. Soc. 125, 4992-4993 (2003).
[Summary] [Full text] [Rated as a MUST READ paper in Faculty of 1000 (PDF)]
Choi, Y., Kawazoe, Y., Murakami, K., Misawa, H., & Uesugi, M
Identification of bioactive molecules by adipogenesis profiling of organic compounds.
J. Biol. Chem. 278, 7320-7324 (2003).
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Asada, S., Choi, Y., Yamada, M., Wang, S., Hung, M., Qin, J., & Uesugi, M.
External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator.
Proc. Natl. Acad. Sci. USA 99, 12747-12752 (2002).
[Summary] [Full text] [News in Biocentury Magazine (PDF)]
Choi, Y., Asada, S., & Uesugi, M.
Divergent hTAF(II)31-binding motifs hidden in activation domains.
J. Biol. Chem. 275, 15912-15916 (2000) .
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Uesugi, M. & Verdine, G. L.
The alpha helical FXXphiphi motif in p53: TAF interaction and discrimination by MDM2.
Proc. Natl. Acad. Sci. USA 96, 14801-14806 (1999) .
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Nyanguile, O., Uesugi, M., Austin, D. J., & Verdine, G. L.
A non-natural transcriptional coactivator.
Proc. Natl. Acad. Sci. USA 94, 13402-13406 (1997) .
[Summary] [Full text][PNAS Commentary (PDF)]
Uesugi, M., Nyanguile, O., Lu, H., Levine, A. J., & Verdine, G. L.
Induced alpha helix in the VP16 activation domain upon binding to a human TAF.
Science 277, 1310-1313 (1997) .
[Summary] [Full text] [This Week in Science (PDF)]