Uesugi Laboratory
代表的論文 †
Kamisuki, S., Shirakawa T., Kugimiya, A., Abu-Elheiga, L., Choo, H.-Y., Yamada, K., Shimogawa, H., Wakil, S. J., Uesugi, M.
Synthesis and eveluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.
J. Med. Chem. in press (2011).
Kawazoe, Y., Shimogawa, H., Sato, A., Uesugi, M.
Mitochondrial surface-specific fluorescent probe activated by bioconversion.
Angew. Chem. Int. Ed. 50(24), 5478-5481 (2011).
Sumiya, E., Shimogawa, H., Sasaki, H., Tsutsumi, M., Yoshita, K., Ojika, M., Suenaga, K., Uesugi, M.
Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin-filament stabilizers.
ACS Chem. Biol. 6, 425-431 (2011).
Shirakawa, T. Kawazoe, Y., Tsujikawa, T., Jung, D., Sato, S., Uesugi, M.
Deactivation of STAT6 through Serine 707 phosphorylation by JNK.
J. Biol. Chem. 286, 4003-4010 (2011).
[Summary]
Sato, S., Murata, A., Orihara, T., Shirakawa, T., Suenaga, K., Kigoshi, H., Uesugi, M.
Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin.
Chem. Biol. 18 (1), 31-139 (2011).
[Summary]
Sato, S. Murata, A., Shirakawa, T., Uesugi, M.
Biochemical target isolation for novices: Affinity-based strategies. (Review)
Chem. Biol. 17 (6), 616-623 (2010).
[Summary]
Kamisuki, S., Mao, Q., Abu-Eliheiga, L., Gu, Z., Kugimiya, A., Kwon, Y., Shinohara, T., Kawazoe, Y., Sato, S. Asakura, K., Choo, H., Sakai, J., Wakil, SJ., Uesugi, M.
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.
Chem. Biol. 16 (8), 882-892 (2009).
[Fulltext]
Yamazoe, S., Shimogawa, H., Sato, S., Esko, J. D., Uesugi, M.
A dumbbell-shaped small molecule that promotes cell adhesion and growth.
Chem. Biol. 16 (7), 773-782 (2009)
[Fulltext]
Jung, D., Shimogawa, H., Kwon, Y., Mao, Q., Sato, S., Kamisuki, S., Kigoshi, H., Uesugi, M.
Wrenchnolol derivative optimized for gene activation in cells.
J. Am. Chem. Soc. 131(13), 4774-4782 (2009)
[Fulltext]
Sato, S., Kwon, Y., Kamisuki, S., Srivastava, N., Mao, Q., Kawazoe, Y., Uesugi, M.
Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin.
J. Am. Chem. Soc. 129(4), 873-880 (2007)
[Summary] [Fulltext] [News Rx]
Choi, Y., Shimogawa, H., Murakami, K., Ramdas, L., Zhang, W., Qin, J., Uesugi,M.
Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2
Chem. Biol, 13, 241-249 (2006)．
[Summary] [Fulltext]
Kawazoe, Y., Tanaka, H., Uesugi, M.
Chemical genetic identification of histamine receptor H1 as a stimulator of insulin-induced adipogenesis.
Chem. Biol.11, 907-913 (2004).
Kwon,Y., Arndt, H., Mao, Q., Choi, Y., Kawazoe, Y., Dervan, P. B., Uesugi, M.
Small molecule transcription factor mimic.
J. Am. Chem. Soc. 126, 15940-15941 (2004).
[Summary] [Full text]
Shimogawa, H., Kwon, Y., Mao, Q., Kawazoe, Y., Choi, Y., Asada, S., Kigoshi, H., & Uesugi, M.
A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.
J. Am. Chem. Soc. 126, 3461-3471 (2004).
[Summary] [Full text] [C&EN(PDF)]
Asada, S., Choi, Y., & Uesugi, M.
A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction.
J. Am. Chem. Soc. 125, 4992-4993 (2003).
[Summary] [Full text] [Rated as a MUST READ paper in Faculty of 1000 (PDF)]
Choi, Y., Kawazoe, Y., Murakami, K., Misawa, H., & Uesugi, M
Identification of bioactive molecules by adipogenesis profiling of organic compounds.
J. Biol. Chem. 278, 7320-7324 (2003).
[Summary] [Full text]
Asada, S., Choi, Y., Yamada, M., Wang, S., Hung, M., Qin, J., & Uesugi, M.
External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator.
Proc. Natl. Acad. Sci. USA 99, 12747-12752 (2002).
[Summary] [Full text] [News in Biocentury Magazine (PDF)]
Choi, Y., Asada, S., & Uesugi, M.
Divergent hTAF(II)31-binding motifs hidden in activation domains.
J. Biol. Chem. 275, 15912-15916 (2000) .
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Uesugi, M. & Verdine, G. L.
The alpha helical FXXphiphi motif in p53: TAF interaction and discrimination by MDM2.
Proc. Natl. Acad. Sci. USA 96, 14801-14806 (1999) .
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Nyanguile, O., Uesugi, M., Austin, D. J., & Verdine, G. L.
A non-natural transcriptional coactivator.
Proc. Natl. Acad. Sci. USA 94, 13402-13406 (1997) .
[Summary] [Full text][PNAS Commentary (PDF)]
Uesugi, M., Nyanguile, O., Lu, H., Levine, A. J., & Verdine, G. L.
Induced alpha helix in the VP16 activation domain upon binding to a human TAF.
Science 277, 1310-1313 (1997) .
[Summary] [Full text] [This Week in Science (PDF)]