- 追加された行はこの色です。
- 削除された行はこの色です。
*代表的論文 [#n710f466]
Kamisuki, S., Mao, Q., Abu-Eliheiga, L., Gu, Z., Kugimiya, A., Kwon, Y., Shinohara, T., Kawazoe, Y., Sato, S. Asakura, K., Choo, H., Sakai, J., Wakil, SJ., Uesugi, M.~
''A Small Molecule that Blocks Fat Synthesis by Inhibiting the Activation of SREBP''.~
Chem. Bilo. 16 (8), 882-892(2009).~
&ref(C&B2009_Kamisuki.pdf,noicon,noimg,nolink,[Fulltext] );
Kamisuki, S., Shirakawa T., Kugimiya, A., Abu-Elheiga, L., Choo, H.-Y., Yamada, K., Shimogawa, H., Wakil, S. J., Uesugi, M.~
''Synthesis and eveluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.''~
J. Med. Chem. in press (2011).~
~
Kawazoe, Y., Shimogawa, H., Sato, A., Uesugi, M.~
''Mitochondrial surface-specific fluorescent probe activated by bioconversion.''~
Angew. Chem. Int. Ed. 50(24), 5478-5481 (2011).~
~
Sumiya, E., Shimogawa, H., Sasaki, H., Tsutsumi, M., Yoshita, K., Ojika, M., Suenaga, K., Uesugi, M.~
''Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin-filament stabilizers''.~
ACS Chem. Biol. 6, 425-431 (2011).~
~
Shirakawa, T. Kawazoe, Y., Tsujikawa, T., Jung, D., Sato, S., Uesugi, M.~
''Deactivation of STAT6 through Serine 707 phosphorylation by JNK''.~
J. Biol. Chem. 286, 4003-4010 (2011).~
[[[Summary>http://www.ncbi.nlm.nih.gov/pubmed/21123173]]]~
~
Sato, S., Murata, A., Orihara, T., Shirakawa, T., Suenaga, K., Kigoshi, H., Uesugi, M.~
''Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin''.~
Chem. Biol. 18 (1), 31-139 (2011).~
[[[Summary>http://www.ncbi.nlm.nih.gov/pubmed/21276946]]]~
Sato, S. Murata, A., Shirakawa, T., Uesugi, M.~
''Biochemical target isolation for novices: Affinity-based strategies''. (Review)~
Chem. Biol. 17 (6), 616-623 (2010).~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/20609411]]~
~
Kamisuki, S., Mao, Q., Abu-Eliheiga, L., Gu, Z., Kugimiya, A., Kwon, Y., Shinohara, T., Kawazoe, Y., Sato, S. Asakura, K., Choo, H., Sakai, J., Wakil, SJ., Uesugi, M.~
''A small molecule that blocks fat synthesis by inhibiting the activation of SREBP''.~
Chem. Biol. 16 (8), 882-892 (2009).~
&ref(C&B2009_Kamisuki.pdf,noicon,noimg,nolink,[Fulltext] );~
~
Yamazoe, S., Shimogawa, H., Sato, S., Esko, J. D., Uesugi, M.~
''A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth.''~
''A dumbbell-shaped small molecule that promotes cell adhesion and growth.''~
Chem. Biol. 16 (7), 773-782 (2009)~
&ref(C&B2009_Yamazoe.pdf,noicon,noimg,nolink,[Fulltext] );
&ref(C&B2009_Yamazoe.pdf,noicon,noimg,nolink,[Fulltext] );~
~
Jung, D., Shimogawa, H., Kwon, Y., Mao, Q., Sato, S., Kamisuki, S., Kigoshi, H., Uesugi, M.~
''Wrenchnolol Derivative Optimized for Gene Activation in Cells.''~
''Wrenchnolol derivative optimized for gene activation in cells.''~
J. Am. Chem. Soc. 131(13), 4774-4782 (2009)~
&ref(JACS_2009_Jung.pdf,noicon,noimg,nolink,[Fulltext] );
&ref(JACS_2009_Jung.pdf,noicon,noimg,nolink,[Fulltext] );~
~
Sato, S., Kwon, Y., Kamisuki, S., Srivastava, N., Mao, Q., Kawazoe, Y., Uesugi, M.~
''Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin.''~
J. Am. Chem. Soc. 129(4), 873-880 (2007)~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/17243824?dopt=AbstractPlus]] &ref(ja0655643.pdf,noicon,noimg,nolink,[Fulltext] ); &ref(Pharmabusinessweek.pdf,noicon,noimg,nolink,[News Rx] );~
~
Choi, Y., Shimogawa, H., Murakami, K., Ramdas, L., Zhang, W., Qin, J., Uesugi,M.~
''Chemical Genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2''~
Chemistry＆Biology, 13, 241-249 (2006)．~
[[[Summary]:http://www.ncbi.nlm.nih.gov/pubmed/16638529?dopt=Abstract]] &ref(C&B_choi_2006.pdf,noicon,noimg,nolink,[Fulltext] );
''Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2''~
Chem. Biol, 13, 241-249 (2006)．~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/16638529?dopt=Abstract]] &ref(C&B_choi_2006.pdf,noicon,noimg,nolink,[Fulltext] ); ~
~
Kawazoe, Y., Tanaka, H., Uesugi, M.~
''Chemical genetic identification of histamine receptor H1 as a stimulator of insulin-induced adipogenesis.''~
Chem. Biol.11, 907-913 (2004).~
~
Kwon,Y., Arndt, H., Mao, Q., Choi, Y., Kawazoe, Y., Dervan, P. B., Uesugi, M.~
''Small molecule transcription factor mimic.''~
J. Am. Chem. Soc. 126, 15940-15941 (2004).~
[[[Summary]:http://www.ncbi.nlm.nih.gov/pubmed/15584709?dopt=Abstract]]
&ref(JACS_2004.pdf,noicon,noimg,nolink,[Full text] );~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/15584709?dopt=Abstract]] &ref(JACS_2004.pdf,noicon,noimg,nolink,[Full text] );~
~
Shimogawa, H., Kwon, Y., Mao, Q., Kawazoe, Y., Choi, Y., Asada, S., Kigoshi, H., & Uesugi, M.~
''A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.''~
J. Am. Chem. Soc. 126, 3461-3471 (2004).~
[[[Summary]:http://www.ncbi.nlm.nih.gov/pubmed/15025473?dopt=Abstract]] &ref(JACS_2004_shimogawa.pdf,noicon,noimg,nolink,[Full text] ); &ref(wrench-article.pdf,noicon,noimg,nolink,[C&EN(PDF)] );~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/15025473?dopt=Abstract]] &ref(JACS_2004_shimogawa.pdf,noicon,noimg,nolink,[Full text] ); &ref(wrench-article.pdf,noicon,noimg,nolink,[C&EN(PDF)] );~
~
Asada, S., Choi, Y., & Uesugi, M.~
''A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction.''~
J. Am. Chem. Soc. 125, 4992-4993 (2003).~
[[[Summary]:http://www.ncbi.nlm.nih.gov/pubmed/12708845?dopt=Abstract]] &ref(JACS_2003_asada.pdf,noicon,noimg,nolink,[Full text] ); &ref(AsadaJACS_faculty1000.pdf,noicon,noimg,nolink,[Rated as a MUST READ paper in Faculty of 1000 (PDF)] );~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12708845?dopt=Abstract]] &ref(JACS_2003_asada.pdf,noicon,noimg,nolink,[Full text] ); &ref(AsadaJACS_faculty1000.pdf,noicon,noimg,nolink,[Rated as a MUST READ paper in Faculty of 1000 (PDF)] );~
~
Choi, Y., Kawazoe, Y., Murakami, K., Misawa, H., & Uesugi, M~
''Identification of bioactive molecules by adipogenesis profiling of organic compounds.''~
J. Biol. Chem. 278, 7320-7324 (2003).~
[[[Summary]:http://www.ncbi.nlm.nih.gov/pubmed/12496288?dopt=Abstract]] &ref(JBC_2003_choi.pdf,noicon,noimg,nolink,[Full text]);~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12496288?dopt=Abstract]] &ref(JBC_2003_choi.pdf,noicon,noimg,nolink,[Full text]);~
~
Asada, S., Choi, Y., Yamada, M., Wang, S., Hung, M., Qin, J., & Uesugi, M.~
''External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator.''~
Proc. Natl. Acad. Sci. USA 99, 12747-12752 (2002).~
[[[Summary]:http://www.ncbi.nlm.nih.gov/pubmed/12242338?dopt=Abstract]] &ref(PNAS_2002_asada.pdf,noicon,noimg,nolink,[Full text]); &ref(PNAS_2002_biocenturry.pdf,noicon,noimg,nolink,[News in Biocentury Magazine (PDF)]);~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12242338?dopt=Abstract]] &ref(PNAS_2002_asada.pdf,noicon,noimg,nolink,[Full text]); &ref(PNAS_2002_biocenturry.pdf,noicon,noimg,nolink,[News in Biocentury Magazine (PDF)]);~
~
Choi, Y., Asada, S., & Uesugi, M.~
''Divergent hTAF(II)31-binding motifs hidden in activation domains.''~
J. Biol. Chem. 275, 15912-15916 (2000) .~
[[[Summary]:http://www.ncbi.nlm.nih.gov/pubmed/10821850?dopt=Abstract]] &ref(JBC_2000.pdf,noicon,noimg,nolink,[Full text]);~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/10821850?dopt=Abstract]] &ref(JBC_2000.pdf,noicon,noimg,nolink,[Full text]);~
~
Uesugi, M. & Verdine, G. L.~
''The alpha helical FXXphiphi motif in p53: TAF interaction and discrimination by MDM2.''~
Proc. Natl. Acad. Sci. USA 96, 14801-14806 (1999) .~
[[[Summary]:http://www.ncbi.nlm.nih.gov/pubmed/10611293?dopt=Abstract]] &ref(PNAS_99.pdf,noicon,noimg,nolink,[Full text]);~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/10611293?dopt=Abstract]] &ref(PNAS_99.pdf,noicon,noimg,nolink,[Full text]);~
~
Nyanguile, O., Uesugi, M., Austin, D. J., & Verdine, G. L.~
''A non-natural transcriptional coactivator.''~
Proc. Natl. Acad. Sci. USA 94, 13402-13406 (1997) .~
[[[Summary]:http://www.ncbi.nlm.nih.gov/pubmed/9391036?dopt=Abstract]] &ref(PNAS_97.pdf,noicon,noimg,nolink,[Full text]);&ref(PNAS_97_Commentary_97.pdf,noicon,noimg,nolink,[PNAS Commentary (PDF)]);~
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/9391036?dopt=Abstract]] &ref(PNAS_97.pdf,noicon,noimg,nolink,[Full text]);&ref(PNAS_97_Commentary_97.pdf,noicon,noimg,nolink,[PNAS Commentary (PDF)]);~
~
Uesugi, M., Nyanguile, O., Lu, H., Levine, A. J., & Verdine, G. L.~
''Induced alpha helix in the VP16 activation domain upon binding to a human TAF.''~
Science 277, 1310-1313 (1997) .~
[[[Summary]:http://www.ncbi.nlm.nih.gov/pubmed/9271577?dopt=Abstract]] &ref(Science_97.pdf,noicon,noimg,nolink,[Full text]); &ref(Science_97_thisweek.pdf,noicon,noimg,nolink,[This Week in Science (PDF)]);
[[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/9271577?dopt=Abstract]] &ref(Science_97.pdf,noicon,noimg,nolink,[Full text]); &ref(Science_97_thisweek.pdf,noicon,noimg,nolink,[This Week in Science (PDF)]);
