- 追加された行はこの色です。
- 削除された行はこの色です。
*代表的論文 [#n710f466] Kamisuki, S., Shirakawa T., Kugimiya, A., Abu-Elheiga, L., Choo, H.-Y., Yamada, K., Shimogawa, H., Wakil, S. J., Uesugi, M.~ ''Synthesis and eveluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.''~ J. Med. Chem. in press (2011).~ ~ Kawazoe, Y., Shimogawa, H., Sato, A., Uesugi, M.~ ''Mitochondrial surface-specific fluorescent probe activated by bioconversion.''~ Angew. Chem. Int. Ed. 50(24), 5478-5481 (2011).~ ~ Sumiya, E., Shimogawa, H., Sasaki, H., Tsutsumi, M., Yoshita, K., Ojika, M., Suenaga, K., Uesugi, M.~ ''Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin-filament stabilizers''.~ ACS Chem. Biol. 6, 425-431 (2011).~ ~ Shirakawa, T. Kawazoe, Y., Tsujikawa, T., Jung, D., Sato, S., Uesugi, M.~ ''Deactivation of STAT6 through Serine 707 phosphorylation by JNK''.~ J. Biol. Chem. 286, 4003-4010 (2011).~ [[[Summary>http://www.ncbi.nlm.nih.gov/pubmed/21123173]]]~ ~ Sato, S., Murata, A., Orihara, T., Shirakawa, T., Suenaga, K., Kigoshi, H., Uesugi, M.~ ''Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin''.~ Chem. Biol. 18 (1), 31-139 (2011).~ [[[Summary>http://www.ncbi.nlm.nih.gov/pubmed/21276946]]]~ Sato, S. Murata, A., Shirakawa, T., Uesugi, M.~ ''Biochemical target isolation for novices: Affinity-based strategies''. (Review)~ Chem. Biol. 17 (6), 616-623 (2010).~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/20609411]]~ ~ Kamisuki, S., Mao, Q., Abu-Eliheiga, L., Gu, Z., Kugimiya, A., Kwon, Y., Shinohara, T., Kawazoe, Y., Sato, S. Asakura, K., Choo, H., Sakai, J., Wakil, SJ., Uesugi, M.~ ''A small molecule that blocks fat synthesis by inhibiting the activation of SREBP''.~ Chem. Biol. 16 (8), 882-892 (2009).~ &ref(C&B2009_Kamisuki.pdf,noicon,noimg,nolink,[Fulltext] );~ ~ Yamazoe, S., Shimogawa, H., Sato, S., Esko, J. D., Uesugi, M.~ ''A dumbbell-shaped small molecule that promotes cell adhesion and growth.''~ Chem. Biol. 16 (7), 773-782 (2009)~ &ref(C&B2009_Yamazoe.pdf,noicon,noimg,nolink,[Fulltext] );~ ~ Jung, D., Shimogawa, H., Kwon, Y., Mao, Q., Sato, S., Kamisuki, S., Kigoshi, H., Uesugi, M.~ ''Wrenchnolol derivative optimized for gene activation in cells.''~ J. Am. Chem. Soc. 131(13), 4774-4782 (2009)~ &ref(JACS_2009_Jung.pdf,noicon,noimg,nolink,[Fulltext] );~ ~ Sato, S., Kwon, Y., Kamisuki, S., Srivastava, N., Mao, Q., Kawazoe, Y., Uesugi, M.~ ''Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin.''~ J. Am. Chem. Soc. 129(4), 873-880 (2007)~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/17243824?dopt=AbstractPlus]] &ref(ja0655643.pdf,noicon,noimg,nolink,[Fulltext] ); &ref(Pharmabusinessweek.pdf,noicon,noimg,nolink,[News Rx] );~ ~ Choi, Y., Shimogawa, H., Murakami, K., Ramdas, L., Zhang, W., Qin, J., Uesugi,M.~ ''Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2''~ Chem. Biol, 13, 241-249 (2006).~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/16638529?dopt=Abstract]] &ref(C&B_choi_2006.pdf,noicon,noimg,nolink,[Fulltext] ); ~ ~ Kawazoe, Y., Tanaka, H., Uesugi, M.~ ''Chemical genetic identification of histamine receptor H1 as a stimulator of insulin-induced adipogenesis.''~ Chem. Biol.11, 907-913 (2004).~ ~ Kwon,Y., Arndt, H., Mao, Q., Choi, Y., Kawazoe, Y., Dervan, P. B., Uesugi, M.~ ''Small molecule transcription factor mimic.''~ J. Am. Chem. Soc. 126, 15940-15941 (2004).~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/15584709?dopt=Abstract]] &ref(JACS_2004.pdf,noicon,noimg,nolink,[Full text] );~ ~ Shimogawa, H., Kwon, Y., Mao, Q., Kawazoe, Y., Choi, Y., Asada, S., Kigoshi, H., & Uesugi, M.~ ''A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.''~ J. Am. Chem. Soc. 126, 3461-3471 (2004).~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/15025473?dopt=Abstract]] &ref(JACS_2004_shimogawa.pdf,noicon,noimg,nolink,[Full text] ); &ref(wrench-article.pdf,noicon,noimg,nolink,[C&EN(PDF)] );~ ~ Asada, S., Choi, Y., & Uesugi, M.~ ''A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction.''~ J. Am. Chem. Soc. 125, 4992-4993 (2003).~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12708845?dopt=Abstract]] &ref(JACS_2003_asada.pdf,noicon,noimg,nolink,[Full text] ); &ref(AsadaJACS_faculty1000.pdf,noicon,noimg,nolink,[Rated as a MUST READ paper in Faculty of 1000 (PDF)] );~ ~ Choi, Y., Kawazoe, Y., Murakami, K., Misawa, H., & Uesugi, M~ ''Identification of bioactive molecules by adipogenesis profiling of organic compounds.''~ J. Biol. Chem. 278, 7320-7324 (2003).~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12496288?dopt=Abstract]] &ref(JBC_2003_choi.pdf,noicon,noimg,nolink,[Full text]);~ ~ Asada, S., Choi, Y., Yamada, M., Wang, S., Hung, M., Qin, J., & Uesugi, M.~ ''External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator.''~ Proc. Natl. Acad. Sci. USA 99, 12747-12752 (2002).~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/12242338?dopt=Abstract]] &ref(PNAS_2002_asada.pdf,noicon,noimg,nolink,[Full text]); &ref(PNAS_2002_biocenturry.pdf,noicon,noimg,nolink,[News in Biocentury Magazine (PDF)]);~ ~ Choi, Y., Asada, S., & Uesugi, M.~ ''Divergent hTAF(II)31-binding motifs hidden in activation domains.''~ J. Biol. Chem. 275, 15912-15916 (2000) .~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/10821850?dopt=Abstract]] &ref(JBC_2000.pdf,noicon,noimg,nolink,[Full text]);~ ~ Uesugi, M. & Verdine, G. L.~ ''The alpha helical FXXphiphi motif in p53: TAF interaction and discrimination by MDM2.''~ Proc. Natl. Acad. Sci. USA 96, 14801-14806 (1999) .~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/10611293?dopt=Abstract]] &ref(PNAS_99.pdf,noicon,noimg,nolink,[Full text]);~ ~ Nyanguile, O., Uesugi, M., Austin, D. J., & Verdine, G. L.~ ''A non-natural transcriptional coactivator.''~ Proc. Natl. Acad. Sci. USA 94, 13402-13406 (1997) .~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/9391036?dopt=Abstract]] &ref(PNAS_97.pdf,noicon,noimg,nolink,[Full text]);&ref(PNAS_97_Commentary_97.pdf,noicon,noimg,nolink,[PNAS Commentary (PDF)]);~ ~ Uesugi, M., Nyanguile, O., Lu, H., Levine, A. J., & Verdine, G. L.~ ''Induced alpha helix in the VP16 activation domain upon binding to a human TAF.''~ Science 277, 1310-1313 (1997) .~ [[[Summary]>http://www.ncbi.nlm.nih.gov/pubmed/9271577?dopt=Abstract]] &ref(Science_97.pdf,noicon,noimg,nolink,[Full text]); &ref(Science_97_thisweek.pdf,noicon,noimg,nolink,[This Week in Science (PDF)]);