Uesugi Laboratory

開始行:
|&ref(ti02.jpg,nolink,40%);|&size(60){&color(#666){''Rese... ~ #ref(research00.jpg,nolink,center,36%) ''~ '' **''Create New World of Bioactive Synthetic Molecules''&b... As biological processes all stem from chemical events, it... **''ケミカルバイオロジー～化学を起点とした生物学'' [#wb3a... ケミカルバイオロジーとは、化学を起点とした生物学です。生... ''~ '' *Selected Publications [#w3c77657] **''Covalent Plant Natural Product that Potentiates Antit... ***Takemoto, M., Delghandi, S., Abo, M., Yurimoto, K., Od... '''''J. Am. Chem. Soc.''''' 147(3), 2902–2912 (2025)~ https://doi.org/10.1021/jacs.4c17837 #ref(TOC_20240227.png,nolink,40%) **''Chemoproteomic Identification of Spermidine-Binding P... ***Singh, V., Hirose, S., Takemoto, M., Farrag, A., Sato,... '''''J. Am. Chem. Soc.''''' 146(24), 16412–16418 (2... https://doi.org/10.1021/jacs.3c14615 #ref(20240612.png,nolink,80%) **''Identification of a Self-Assembling Small-Molecule Ca... ***Zhuo, S., Noda, N., Hioki, K., Jin, S., Hayashi, T., H... '''''J. Med. Chem.''''' 66(18), 13266–13279 (2023)~ https://doi.org/10.1021/acs.jmedchem.3c01252 #ref((2023) Identification of a Self-Assembling Small-Mol... **''Chemoproteomic Identification of Blue-Light-Damaged P... ***Toh, K., Nishio, K., Nakagawa, R., Egoshi, S., Abo, M.... '''''J. Am. Chem. Soc. ''''' 144(44), 20171–20176 (... https://doi.org/10.1021/jacs.2c07180 #ref((2022) Chemoproteomic Identification of Blue-Light-D... **''Magnetic Control of Cells by Chemical Fabrication of ... ***Nishio, K., Toh, K., Perron, A., Goto, M., Abo, M.... '''''J. Am. Chem. Soc.''''' 144(37), 16720–16725 (2... https://doi.org/10.1021/jacs.2c06555 #ref((2022)Magnetic Control of Cells by Chemical Fabricat... **''Discovery of a phase-separating small molecule that s... ***Ado, G., Noda, N., Vu, H., Perron, A., Mahapatra, ... '''''Chemical Science''''' 13, 5760-5766 (2022)~ https://doi.org/10.1039/D1SC07151C #ref((2022) Discovery of a phase-separating small molecul... **''Glucose as a Protein-Condensing Cellular Solute'' [#n... ***Noda, N., Jung, Y., Ado, G., Mizuhata, Y., Higuchi... '''''ACS Chem. Biol.''''' 17(3), 567–575 (2022)~ https://doi.org/10.1021/acschembio.1c00849 #ref((2022)Glucose as a Protein-Condensing Cellular Solut... **''Controlled lipid β-oxidation and carnitine biosynthes... ***Mendoza, A., Takemoto, Y., Cruzado, K., Masoud, S.,... '''''Cell Chemical Biology''''' 29(4), 660-669 (2022)~ https://doi.org/10.1016/j.chembiol.2021.08.008 #ref((2021) Controlled lipid β-oxidation and carnitine bi... **''Chemical Genetics Reveals a Role of Squalene Synthase... ***Takemoto, Y., Kadota, S., Minami, I., Otsuka, S., ... '''''Angew. Chem. Int. Ed.''''' 60(40), 21824-21831 (20... https://doi.org/10.1002/anie.202100523 #ref((2021) Chemical Genetics Reveals a Role of Squalene ... **''Discovery of Self‐Assembling Small Molecules as Vacci... ***Jin, S., Vu, H., Hioki, K., Noda, N., Yoshida, H.,... '''''Angew. Chem. Int. Ed.''''' 60(2), 961-969 (2021)~ https://doi.org/10.1002/anie.202011604 #ref((2020) Discovery of Self‐Assembling Small Molecules ... **''Chemoproteomic Profiling of a Pharmacophore-Focused C... ***Punzalan, L., Jiang, L., Mao, D., Mahapatra, A., S... '''''Cell Chemical Biology''''' 27(6), 708–718 (... https://doi.org/10.1016/j.chembiol.2020.04.007 #ref(research2020-2.png,nolink,70%) **''Discovery of a Small-Molecule-Dependent Photolytic Pe... ***Takemoto, Y., Mao, Di., Punzalan, L., Götze, S... '''''J. Am. Chem. Soc.''''' 142(3), 1142-1146 (2020)~ https://doi.org/10.1021/jacs.9b09178 #ref(research38 (2020).jpg,nolink,30%) **''Nutrient-Based Chemical Library as a Source of Energy... ***Furuta,T., Mizukami, Y., Asano, L., Kotake, K., Zi... '''''ACS Chem. Biol.''''' 14(9), 1860-1865 (2019)~ https://doi.org/10.1021/acschembio.9b00444 #ref(Nutrient-Based Chemical Library as a Source of Energ... **''Vitamin D metabolite, 25-Hydroxyvitamin D, regulates ... ***Asano, L., Watanabe, M., Ryoden, Y., Usuda, K., Yamagu... '''''Cell Chem Biol.''''' 24, 207-217 (2017)~ https://doi.org/10.1016/j.chembiol.2016.12.017 #ref(research01.jpg,nolink,375x375) **''A synthetic hybrid molecule for the selective removal... ***Mao, D., Ando, S., Sato, S., Qin, Y., Hirata, N., Kats... '''''Angew. Chem. Int. Ed.''''' 56(7), 1765-1770 (2017)~ https://doi.org/10.1002/anie.201610284 #ref(research02.jpg,nolink,75%) **''A small molecule that represses translation of G-quad... ***Katsuda, Y., Sato, S., Asano, L., Morimura, Y., Furuta... '''''J. Am. Chem. Soc.''''' 138, 9037-9040 (2016)~ https://doi.org/10.1021/jacs.6b04506 #ref(research03.gif,nolink,350x148) **''A potent and site-selective agonist of TRPA1.'' [#b35... ***Takaya, J., Mio, K., Shiraishi, T., Kurokawa, T., Otsu... '''''J. Am. Chem. Soc.''''' 137, 15859−15864 (2015)~ https://doi.org/10.1021/jacs.5b10162 #ref(research04.gif,nolink,350x205) **''Intracellular generation of a diterpene-peptide conju... ***Parvatkar, P., Kato, N., Uesugi, M., Sato, S., Ohkanda... '''''J. Am. Chem. Soc.''''' 137, 15624-15627 (2015)~ https://doi.org/10.1021/jacs.5b09817 #ref(research05.gif,nolink,350x185) **''Live-cell imaging of endogenous mRNAs with a small mo... ***Sato, S., Watanabe, M., Katsuda, Y., Murata, A., Wang,... '''''Angew. Chem. Int. Ed.''''' 54(6), 1855-1858 (2015)~ https://doi.org/10.1002/anie.201410339 #ref(research06.png,nolink,800x142) **''Synthetic molecules that protect cells from anoikis a... ***Frisco-Cabanos, H.L., Watanabe, M., Okumura, N., Kusam... '''''Angew. Chem. Int. Ed.''''' 53(42), 11208-11213 (2014)~ https://doi.org/10.1002/anie.201405829 #ref(research07.jpg,nolink,350x322) **''Selective elimination of human pluripotent stem cells... ***Kuo, T.F., Mao, D., Hirata, N., Khambu, B., Kimura, Y.... '''''J. Am. Chem. Soc.''''' 136 (28), 9798-9801 (2014)~ https://doi.org/10.1021/ja501795c #ref(research08.gif,nolink,350x144) **''A chemical probe that labels human pluripotent stem c... ***Hirata, N., Nakagawa, M., Fujibayashi, Y., Yamauchi, K... '''''Cell Rep''''' 6., 1165–1174 (2014)~ https://doi.org/10.1016/j.celrep.2014.02.006 #ref(research09.jpg,nolink,375x375) **''VMAT2 identified as a regulator of late-stage beta ce... ***Sakano, D., Shiraki, N., Kikawa, K., Yamazoe, T., Kata... '''''Nat. Chem. Biol.''''' 10, 141-148 (2014)~ https://doi.org/10.1038/nchembio.1410 #ref(research10.png,nolink,350x201) **''Inhibition of microtubule assembly by a complex of ac... ***Kita, M., Hirayama, Y., Yoneda, K., Yamagishi, K., Chi... '''''J. Am. Chem. Soc.''''' 135 (48), 18089-18095 (2013)~ https://doi.org/10.1021/ja406580w #ref(research11.gif,nolink,350x150) **''Small molecule-induced clustering of heparan sulfate ... ***Takemoto, N., Suehara, T., Frisco, H., Sato, S., Sezak... '''''J. Am. Chem. Soc.''''' 135 (30), 11032-11039 (2013)~ https://doi.org/10.1021/ja4018682 #ref(research12.gif,nolink,350x118) **''A small molecule that promotes cardiac differentiatio... ***Minami, I., Yamada, K., Otsuji, T.G., Yamamoto, T., Sh... '''''Cell Rep.''''' (5), 1448-1460 (2012)~ https://doi.org/10.1016/j.celrep.2012.09.015 #ref(research13.jpg,nolink,375x375) **''Synthesis and evaluation of diarylthiazole derivative... ***Kamisuki, S., Shirakawa T., Kugimiya, A., Abu-Elheiga,... '''''J. Med. Chem.''''' 54(13), 4923-4927 (2011)~ https://doi.org/10.1021/jm200304y #ref(research14.gif,nolink,350x272) **''A mitochondrial surface-specific fluorescent probe ac... ***Kawazoe, Y., Shimogawa, H., Sato, A., Uesugi, M. [#s14... '''''Angew. Chem. Int. Ed.''''' 50(24), 5478-5481 (2011)~ https://doi.org/10.1002/anie.201100935 #ref(research15.png,nolink,600x179) **''Marine natural product aurilide activates the OPA1-me... ***Sato, S. Murata, A., Orihara, T., Shirakawa, T., Suena... '''''Chem. Biol.''''' 18 (1), 131-139 (2011)~ https://doi.org/10.1016/j.chembiol.2010.10.017 #ref(research19.png,nolink,350x261) **''A small molecule that blocks fat synthesis by inhibit... ***Kamisuki, S., Mao, Q., Abu-Eliheiga, L., Gu, Z., Kugim... '''''Chem. Biol.''''' 16 (8), 882-892 (2009)~ https://doi.org/10.1016/j.chembiol.2009.07.007 #ref(research21.png,nolink,349x424) **''A dumbbell-shaped small molecule that promotes cell a... ***Yamazoe, S., Shimogawa, H., Sato, S., Esko, J. D., Ues... '''''Chem. Biol.''''' 16 (7), 773-782 (2009)~ https://doi.org/10.1016/j.chembiol.2009.06.008 #ref(research22.png,nolink,350x184) **''Wrenchnolol derivative optimized for gene activation ... ***Jung, D., Shimogawa, H., Kwon, Y., Mao, Q., Sato, S., ... '''''J. Am. Chem. Soc.''''' 131(13), 4774-4782 (2009)~ https://doi.org/10.1021/ja900669k #ref(research23.gif,nolink,350x109) **''Polyproline-rod approach to isolating protein targets... ***Sato, S., Kwon, Y., Kamisuki, S., Srivastava, N., Mao,... '''''J. Am. Chem. Soc.''''' 129(4), 873-880 (2007)~ https://doi.org/10.1021/ja0655643 #ref(research24.gif,nolink,350x161) **''Chemical genetic identification of histamine receptor... ***Kawazoe, Y., Tanaka, H., Uesugi, M. [#kc988134] '''''Chem. Biol.''''' 11, 907-913 (2004)~ https://doi.org/10.1016/j.chembiol.2004.04.017 #ref(research25.png,nolink,350x225) **''Small molecule transcription factor mimic.'' [#hac7c6... ***Kwon,Y., Arndt, H., Mao, Q., Choi, Y., Kawazoe, Y., De... '''''J. Am. Chem. Soc.''''' 126, 15940-15941 (2004)~ https://doi.org/10.1021/ja0445140 #ref(research26.gif,nolink,350x181) **''A wrench-shaped synthetic molecule that modulates a t... ***Shimogawa, H., Kwon, Y., Mao, Q., Kawazoe, Y., Choi, Y... '''''J. Am. Chem. Soc.''''' 126, 3461-3471 (2004)~ https://doi.org/10.1021/ja038855+ #ref(research27.gif,nolink,350x111) **''A gene-expression inhibitor that targets an alpha-hel... ***Asada, S., Choi, Y., & Uesugi, M. [#b995b31a] '''''J. Am. Chem. Soc.''''' 125, 4992-4993 (2003)~ https://doi.org/10.1021/ja0292703 #ref(research28.gif,nolink,350x145) **''External control of Her2 expression and cancer cell g... ***Asada, S., Choi, Y., Yamada, M., Wang, S., Hung, M., Q... '''''Proc. Natl. Acad. Sci. USA''''' 99, 12747-12752 (200... https://doi.org/10.1073/pnas.202162199 #ref(research30.png,nolink,200x366) **''Divergent hTAF(II)31-binding motifs hidden in activat... ***Choi, Y., Asada, S., & Uesugi, M. [#f0157fc1] '''''J. Biol. Chem.''''' 275, 15912-15916 (2000)~ https://doi.org/10.1074/jbc.275.21.15912 #ref(research31.png,nolink,350x337) **''The alpha helical FXXphiphi motif in p53: TAF interac... ***Uesugi, M. & Verdine, G. L. [#n356a1cb] '''''Proc. Natl. Acad. Sci. USA''''' 96, 14801-14806 (199... https://doi.org/10.1073/pnas.96.26.14801 #ref(research32.png,nolink,350x324) **''A non-natural transcriptional coactivator.'' [#r5c782... ***Nyanguile, O., Uesugi, M., Austin, D. J., & Verdin... '''''Proc. Natl. Acad. Sci. USA''''' 94, 13402-13406 (199... https://doi.org/10.1073/pnas.94.25.13402 #ref(research33.png,nolink,350x221) **''Induced alpha helix in the VP16 activation domain upo... ***Uesugi, M., Nyanguile, O., Lu, H., Levine, A. J., &amp... '''''Science''''' 277, 1310-1313 (1997)~ https://doi.org/10.1126/science.277.5330.1310 #ref(research34.png,nolink,350x221)

終了行:
|&ref(ti02.jpg,nolink,40%);|&size(60){&color(#666){''Rese... ~ #ref(research00.jpg,nolink,center,36%) ''~ '' **''Create New World of Bioactive Synthetic Molecules''&b... As biological processes all stem from chemical events, it... **''ケミカルバイオロジー～化学を起点とした生物学'' [#wb3a... ケミカルバイオロジーとは、化学を起点とした生物学です。生... ''~ '' *Selected Publications [#w3c77657] **''Covalent Plant Natural Product that Potentiates Antit... ***Takemoto, M., Delghandi, S., Abo, M., Yurimoto, K., Od... '''''J. Am. Chem. Soc.''''' 147(3), 2902–2912 (2025)~ https://doi.org/10.1021/jacs.4c17837 #ref(TOC_20240227.png,nolink,40%) **''Chemoproteomic Identification of Spermidine-Binding P... ***Singh, V., Hirose, S., Takemoto, M., Farrag, A., Sato,... '''''J. Am. Chem. Soc.''''' 146(24), 16412–16418 (2... https://doi.org/10.1021/jacs.3c14615 #ref(20240612.png,nolink,80%) **''Identification of a Self-Assembling Small-Molecule Ca... ***Zhuo, S., Noda, N., Hioki, K., Jin, S., Hayashi, T., H... '''''J. Med. Chem.''''' 66(18), 13266–13279 (2023)~ https://doi.org/10.1021/acs.jmedchem.3c01252 #ref((2023) Identification of a Self-Assembling Small-Mol... **''Chemoproteomic Identification of Blue-Light-Damaged P... ***Toh, K., Nishio, K., Nakagawa, R., Egoshi, S., Abo, M.... '''''J. Am. Chem. Soc. ''''' 144(44), 20171–20176 (... https://doi.org/10.1021/jacs.2c07180 #ref((2022) Chemoproteomic Identification of Blue-Light-D... **''Magnetic Control of Cells by Chemical Fabrication of ... ***Nishio, K., Toh, K., Perron, A., Goto, M., Abo, M.... '''''J. Am. Chem. Soc.''''' 144(37), 16720–16725 (2... https://doi.org/10.1021/jacs.2c06555 #ref((2022)Magnetic Control of Cells by Chemical Fabricat... **''Discovery of a phase-separating small molecule that s... ***Ado, G., Noda, N., Vu, H., Perron, A., Mahapatra, ... '''''Chemical Science''''' 13, 5760-5766 (2022)~ https://doi.org/10.1039/D1SC07151C #ref((2022) Discovery of a phase-separating small molecul... **''Glucose as a Protein-Condensing Cellular Solute'' [#n... ***Noda, N., Jung, Y., Ado, G., Mizuhata, Y., Higuchi... '''''ACS Chem. Biol.''''' 17(3), 567–575 (2022)~ https://doi.org/10.1021/acschembio.1c00849 #ref((2022)Glucose as a Protein-Condensing Cellular Solut... **''Controlled lipid β-oxidation and carnitine biosynthes... ***Mendoza, A., Takemoto, Y., Cruzado, K., Masoud, S.,... '''''Cell Chemical Biology''''' 29(4), 660-669 (2022)~ https://doi.org/10.1016/j.chembiol.2021.08.008 #ref((2021) Controlled lipid β-oxidation and carnitine bi... **''Chemical Genetics Reveals a Role of Squalene Synthase... ***Takemoto, Y., Kadota, S., Minami, I., Otsuka, S., ... '''''Angew. Chem. Int. Ed.''''' 60(40), 21824-21831 (20... https://doi.org/10.1002/anie.202100523 #ref((2021) Chemical Genetics Reveals a Role of Squalene ... **''Discovery of Self‐Assembling Small Molecules as Vacci... ***Jin, S., Vu, H., Hioki, K., Noda, N., Yoshida, H.,... '''''Angew. Chem. Int. Ed.''''' 60(2), 961-969 (2021)~ https://doi.org/10.1002/anie.202011604 #ref((2020) Discovery of Self‐Assembling Small Molecules ... **''Chemoproteomic Profiling of a Pharmacophore-Focused C... ***Punzalan, L., Jiang, L., Mao, D., Mahapatra, A., S... '''''Cell Chemical Biology''''' 27(6), 708–718 (... https://doi.org/10.1016/j.chembiol.2020.04.007 #ref(research2020-2.png,nolink,70%) **''Discovery of a Small-Molecule-Dependent Photolytic Pe... ***Takemoto, Y., Mao, Di., Punzalan, L., Götze, S... '''''J. Am. Chem. Soc.''''' 142(3), 1142-1146 (2020)~ https://doi.org/10.1021/jacs.9b09178 #ref(research38 (2020).jpg,nolink,30%) **''Nutrient-Based Chemical Library as a Source of Energy... ***Furuta,T., Mizukami, Y., Asano, L., Kotake, K., Zi... '''''ACS Chem. Biol.''''' 14(9), 1860-1865 (2019)~ https://doi.org/10.1021/acschembio.9b00444 #ref(Nutrient-Based Chemical Library as a Source of Energ... **''Vitamin D metabolite, 25-Hydroxyvitamin D, regulates ... ***Asano, L., Watanabe, M., Ryoden, Y., Usuda, K., Yamagu... '''''Cell Chem Biol.''''' 24, 207-217 (2017)~ https://doi.org/10.1016/j.chembiol.2016.12.017 #ref(research01.jpg,nolink,375x375) **''A synthetic hybrid molecule for the selective removal... ***Mao, D., Ando, S., Sato, S., Qin, Y., Hirata, N., Kats... '''''Angew. Chem. Int. Ed.''''' 56(7), 1765-1770 (2017)~ https://doi.org/10.1002/anie.201610284 #ref(research02.jpg,nolink,75%) **''A small molecule that represses translation of G-quad... ***Katsuda, Y., Sato, S., Asano, L., Morimura, Y., Furuta... '''''J. Am. Chem. Soc.''''' 138, 9037-9040 (2016)~ https://doi.org/10.1021/jacs.6b04506 #ref(research03.gif,nolink,350x148) **''A potent and site-selective agonist of TRPA1.'' [#b35... ***Takaya, J., Mio, K., Shiraishi, T., Kurokawa, T., Otsu... '''''J. Am. Chem. Soc.''''' 137, 15859−15864 (2015)~ https://doi.org/10.1021/jacs.5b10162 #ref(research04.gif,nolink,350x205) **''Intracellular generation of a diterpene-peptide conju... ***Parvatkar, P., Kato, N., Uesugi, M., Sato, S., Ohkanda... '''''J. Am. Chem. Soc.''''' 137, 15624-15627 (2015)~ https://doi.org/10.1021/jacs.5b09817 #ref(research05.gif,nolink,350x185) **''Live-cell imaging of endogenous mRNAs with a small mo... ***Sato, S., Watanabe, M., Katsuda, Y., Murata, A., Wang,... '''''Angew. Chem. Int. Ed.''''' 54(6), 1855-1858 (2015)~ https://doi.org/10.1002/anie.201410339 #ref(research06.png,nolink,800x142) **''Synthetic molecules that protect cells from anoikis a... ***Frisco-Cabanos, H.L., Watanabe, M., Okumura, N., Kusam... '''''Angew. Chem. Int. Ed.''''' 53(42), 11208-11213 (2014)~ https://doi.org/10.1002/anie.201405829 #ref(research07.jpg,nolink,350x322) **''Selective elimination of human pluripotent stem cells... ***Kuo, T.F., Mao, D., Hirata, N., Khambu, B., Kimura, Y.... '''''J. Am. Chem. Soc.''''' 136 (28), 9798-9801 (2014)~ https://doi.org/10.1021/ja501795c #ref(research08.gif,nolink,350x144) **''A chemical probe that labels human pluripotent stem c... ***Hirata, N., Nakagawa, M., Fujibayashi, Y., Yamauchi, K... '''''Cell Rep''''' 6., 1165–1174 (2014)~ https://doi.org/10.1016/j.celrep.2014.02.006 #ref(research09.jpg,nolink,375x375) **''VMAT2 identified as a regulator of late-stage beta ce... ***Sakano, D., Shiraki, N., Kikawa, K., Yamazoe, T., Kata... '''''Nat. Chem. Biol.''''' 10, 141-148 (2014)~ https://doi.org/10.1038/nchembio.1410 #ref(research10.png,nolink,350x201) **''Inhibition of microtubule assembly by a complex of ac... ***Kita, M., Hirayama, Y., Yoneda, K., Yamagishi, K., Chi... '''''J. Am. Chem. Soc.''''' 135 (48), 18089-18095 (2013)~ https://doi.org/10.1021/ja406580w #ref(research11.gif,nolink,350x150) **''Small molecule-induced clustering of heparan sulfate ... ***Takemoto, N., Suehara, T., Frisco, H., Sato, S., Sezak... '''''J. Am. Chem. Soc.''''' 135 (30), 11032-11039 (2013)~ https://doi.org/10.1021/ja4018682 #ref(research12.gif,nolink,350x118) **''A small molecule that promotes cardiac differentiatio... ***Minami, I., Yamada, K., Otsuji, T.G., Yamamoto, T., Sh... '''''Cell Rep.''''' (5), 1448-1460 (2012)~ https://doi.org/10.1016/j.celrep.2012.09.015 #ref(research13.jpg,nolink,375x375) **''Synthesis and evaluation of diarylthiazole derivative... ***Kamisuki, S., Shirakawa T., Kugimiya, A., Abu-Elheiga,... '''''J. Med. Chem.''''' 54(13), 4923-4927 (2011)~ https://doi.org/10.1021/jm200304y #ref(research14.gif,nolink,350x272) **''A mitochondrial surface-specific fluorescent probe ac... ***Kawazoe, Y., Shimogawa, H., Sato, A., Uesugi, M. [#s14... '''''Angew. Chem. Int. Ed.''''' 50(24), 5478-5481 (2011)~ https://doi.org/10.1002/anie.201100935 #ref(research15.png,nolink,600x179) **''Marine natural product aurilide activates the OPA1-me... ***Sato, S. Murata, A., Orihara, T., Shirakawa, T., Suena... '''''Chem. Biol.''''' 18 (1), 131-139 (2011)~ https://doi.org/10.1016/j.chembiol.2010.10.017 #ref(research19.png,nolink,350x261) **''A small molecule that blocks fat synthesis by inhibit... ***Kamisuki, S., Mao, Q., Abu-Eliheiga, L., Gu, Z., Kugim... '''''Chem. Biol.''''' 16 (8), 882-892 (2009)~ https://doi.org/10.1016/j.chembiol.2009.07.007 #ref(research21.png,nolink,349x424) **''A dumbbell-shaped small molecule that promotes cell a... ***Yamazoe, S., Shimogawa, H., Sato, S., Esko, J. D., Ues... '''''Chem. Biol.''''' 16 (7), 773-782 (2009)~ https://doi.org/10.1016/j.chembiol.2009.06.008 #ref(research22.png,nolink,350x184) **''Wrenchnolol derivative optimized for gene activation ... ***Jung, D., Shimogawa, H., Kwon, Y., Mao, Q., Sato, S., ... '''''J. Am. Chem. Soc.''''' 131(13), 4774-4782 (2009)~ https://doi.org/10.1021/ja900669k #ref(research23.gif,nolink,350x109) **''Polyproline-rod approach to isolating protein targets... ***Sato, S., Kwon, Y., Kamisuki, S., Srivastava, N., Mao,... '''''J. Am. Chem. Soc.''''' 129(4), 873-880 (2007)~ https://doi.org/10.1021/ja0655643 #ref(research24.gif,nolink,350x161) **''Chemical genetic identification of histamine receptor... ***Kawazoe, Y., Tanaka, H., Uesugi, M. [#kc988134] '''''Chem. Biol.''''' 11, 907-913 (2004)~ https://doi.org/10.1016/j.chembiol.2004.04.017 #ref(research25.png,nolink,350x225) **''Small molecule transcription factor mimic.'' [#hac7c6... ***Kwon,Y., Arndt, H., Mao, Q., Choi, Y., Kawazoe, Y., De... '''''J. Am. Chem. Soc.''''' 126, 15940-15941 (2004)~ https://doi.org/10.1021/ja0445140 #ref(research26.gif,nolink,350x181) **''A wrench-shaped synthetic molecule that modulates a t... ***Shimogawa, H., Kwon, Y., Mao, Q., Kawazoe, Y., Choi, Y... '''''J. Am. Chem. Soc.''''' 126, 3461-3471 (2004)~ https://doi.org/10.1021/ja038855+ #ref(research27.gif,nolink,350x111) **''A gene-expression inhibitor that targets an alpha-hel... ***Asada, S., Choi, Y., & Uesugi, M. [#b995b31a] '''''J. Am. Chem. Soc.''''' 125, 4992-4993 (2003)~ https://doi.org/10.1021/ja0292703 #ref(research28.gif,nolink,350x145) **''External control of Her2 expression and cancer cell g... ***Asada, S., Choi, Y., Yamada, M., Wang, S., Hung, M., Q... '''''Proc. Natl. Acad. Sci. USA''''' 99, 12747-12752 (200... https://doi.org/10.1073/pnas.202162199 #ref(research30.png,nolink,200x366) **''Divergent hTAF(II)31-binding motifs hidden in activat... ***Choi, Y., Asada, S., & Uesugi, M. [#f0157fc1] '''''J. Biol. 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