Hirose Group | ISSP, UTokyo

About Us

Welcome to our research group's website.
"Helices" and "Chirality" are fundamental structures of life universally found in nature.
In our laboratory, we fuse computational science with precision organic synthesis to create unique "Helical π-Conjugated Molecules," challenging the creation of innovative materials that will drive next-generation optical and electronic functions.

Fusion of Computational Science and Precision Synthesis: Rational design and demonstration of functional molecules.
Optical Properties Driven by Structural Specificity: Creation of chiral π-conjugated systems and circularly polarized light functions.
Emergence of Functions through Molecular Assembly: Construction of hierarchical supramolecular architectures.
Materials Science of External Field Responses: Functional design based on light, electromagnetic field, and mechanical interactions.

With the goal of "freely designing the electronic states of organic molecules to elicit their functions," we pioneer next-generation materials science centered on external field responses, taking a broad perspective from single molecules to assembled structures.

The true thrill of university research lies in the experience of tackling questions without known answers and pioneering unique solutions.
In our group, we synthesize organic compounds that no one has ever held before, and unravel their unique physical properties through measurement and analysis.
The intellectual training of generating high-quality ideas through experiments and discussions fosters not only expertise in organic chemistry and condensed matter science, but also the "solid confidence" that will be invaluable in society.
We look forward to hearing from highly motivated students, as well as companies and researchers interested in collaborative research.

News & Topics

2026.04.01 Hirose Laboratory was established at the Kashiwa Campus, The University of Tokyo.
2026.04.01 Our new laboratory website has been launched.
2026.03.20 We attended the 106th CSJ Annual Meeting (2026). Zhang and Gu delivered oral presentations, and Hirose gave an invited lecture.
2026.02.27 Zhang received the 30th ICR Award for Graduate Student from Institute for Chemical Research (ICR), Kyoto University. He also delivered an award-winning presentation at the 125th ICR Research Presentation Meeting.
2026.02.17 Preprint “Topology-Directed π-Extension of Helical PAHs: Tunable Energy Gap and Excited-State Dynamics” has been published on ChemRxiv. [DOI: 10.26434/chemrxiv.15000166/v1]

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Research

Materials Science Based on Chiral Organic Molecules

MolecularWires

Theme 1: Helical Molecular Wires

keywords: Narrow HOMO-LUMO gap, Polyene-like electronic state, Conductance pathway, Ultrafast excited-state dynamics

Nat. Commun. 2022, 13, 1475. <10.1038/s41467-022-29108-8>
Chem. Lett. 2022, 51, 256. <10.1246/cl.210727>
J. Am. Chem. Soc. 2018, 140, 4317. <10.1021/jacs.7b13412>

Theme 2: Circularly Polarized Light-Responsive Materials

keywords: Helically twisted molecular orbitals, Molecular chirality, Selective responsiveness to electromagnetic waves, Transition dipole moment density

Org. Lett. 2025, 27, 11313. <10.1021/acs.orglett.5c03620>
J. Phys. Chem. Lett. 2021, 12, 686. <10.1021/acs.jpclett.0c03174>
Org. Lett. 2020, 22, 9276. <10.1021/acs.orglett.0c03506>

Theme 3: Supramolecular Assembly and Alignment Control

keywords: Chemical modification of helical termini, Intermolecular interactions, Chiral columnar array, Transfer integral, Carrier mobility

J. Am. Chem. Soc. 2025, 147, 25978. <10.1021/jacs.5c08688>

Members

Faculty

Associate Professor　 Takashi HIROSE
Secretary　 Atsuko TSUJI

Students

D3 Weizhe HU (*Grad. Sch. of Eng., Kyoto Univ.)
D3 Jiajian GU (*Grad. Sch. of Eng., Kyoto Univ.)
D3 Zhibo LIU (*Grad. Sch. of Eng., Kyoto Univ.)
M2 Sota MIOMO (*Grad. Sch. of Eng., Kyoto Univ.)